23256-33-9

23256-33-9 structure

Name: Dimaprit dihydrochloride
Chemical Name: Dimaprit dihydrochloride
CAS Number: 23256-33-9
Molecular Formula: C₆H₁₇Cl₂N₃S
Molecular Weight: 234.19000
Catalog: Signaling Pathways GPCR/G Protein Histamine Receptor
Create Date: 2018-10-23 19:16:01
Modify Date: 2024-01-13 17:30:12
Dimaprit dihydrochloride is a selective histamine H2 receptor agonist, it also inhibits nNOS with an IC50 of 49 μM. Dimaprit dihydrochloride can stimulate gastric acid secretion[1][2].

Name	Dimaprit dihydrochloride
Synonyms	S-(3-Dimethylaminopropyl)isothiourea dihydrobromide Carbamimidothioic acid (3-(dimethylamino)propyl ester 3-(dimethylamino)propyl carbamimidothioate,dihydrochloride

Description	Dimaprit dihydrochloride is a selective histamine H2 receptor agonist, it also inhibits nNOS with an IC50 of 49 μM. Dimaprit dihydrochloride can stimulate gastric acid secretion[1][2].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Endocrinology Signaling Pathways >> Immunology/Inflammation >> NO Synthase Signaling Pathways >> GPCR/G Protein >> Histamine Receptor
Target	H2 Receptor nNOS:49 μM (IC50)
In Vitro	Dimaprit has less than 0.0001% the activity of histamine on H1-receptors[1]. Dimaprit (0.1 nM-100 μM) inhibits nNOS concentration dependently with an IC50 of 49±14 μM[2].
In Vivo	Dimaprit stimulates gastric acid secretion in rats (1.25 μM/kg/min; rapid i.v. injection), cats (2-64 μM/h; i.v.) and dogs (1-100 nM/kg/min; i.v.)[1]. Dimaprit (0.01-1 μM/kg; i.v. at intervals of 5 min) causes dose-dependent falls in blood pressure in cats. Dimaprit (1-100 nM; intra-arterial injection) causes vasodilatation in the femoral vascular bed, and it (1 μM/kg; bolus or intravenous injection) has no effect on heart rate[1].
References	[1]. Parsons ME, et, al. Dimaprit -(S-[3-(N,N-dimethylamino)prophyl]isothiourea) - a highly specific histamine H2 -receptor agonist. Part 1. Pharmacology. Agents Actions. 1977 Mar; 7(1): 31-7. [2]. Paquay JB, et, al. Nitric oxide synthase inhibition by dimaprit and dimaprit analogues. Br J Pharmacol. 1999 May; 127(2): 331-4.

CHEMICAL NAME :: Pseudourea, 2-(3-(dimethylamino)propyl)-2-thio-, dihydrochloride

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Hazard Codes	Xi
RIDADR	NONH for all modes of transport
HS Code	2930909090

HS Code	2930909090
Summary	2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%