6104-71-8
6104-71-8 structure
- Name: N-Desmethylclozapine
- Chemical Name: N-desmethylclozapine
- CAS Number: 6104-71-8
- Molecular Formula: C17H17ClN4
- Molecular Weight: 312.79700
- Catalog: analytical chemistry Standard standard material
- Create Date: 2018-12-28 11:33:38
- Modify Date: 2026-07-18 00:51:20
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N-Desmethylclozapine is a dengue virus inhibitor, and an agonist of δ-opioid receptor.
| Name | N-desmethylclozapine |
|---|---|
| Synonyms |
Clozapine IMpurity C
Demethylclozapine Clozapine impurity 3/Clozapine Impurity C/Clozapine impurity A /8-chloro-11-(piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazine N-desmethyl clozapine Norclozapine in methanol 8-Chloro-11-piperazinyl-5H-dibenzo[b,e][1,4]diazine, Norclozapine, Normethylclozapine 8-Chloro-11-(piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazine N-Desmethyl clozapine (Normethylclozapine), Clozapine metabolite. M1 agonist. D2/D3 agonist 3-chloro-6-piperazin-1-yl-5H-benzo[b][1,4]benzodiazepine NORCLOZAPINE; DESMETHYLCLOZAPINE; NORMETHYLCLOZAPINE 8-CHLORO-11-(1-PIPERAZINYL)-5H-DIBENZO[B,E][1,4]DIAZINE N-Desmethyl Clozapine-d8 hydrochloride Norclozapine Solution, 100ppm Desmethylclozapine CLOZAPINE, NORMETHYL(NORMETHYLCLOZAPINE, NOR-CLOZAPINE, DESMETHYLC NORCLOZAPINE 8-Chloro-11-(piperazin-1-yl)-5H-dib Clozapine Impurity 3(Clozapine Impurity C) 8-CHLORO-11-PIPERAZINYL-5H-DIBENZO[B,E][1,4]DIAZINE Norclozapine (A-104) Desmethylclozapine (Norclozapine) 6-chloro-10-(piperazin-1-yl)-2,9-diazatricyclo[9.4.0.03,]pentadeca-1,3,4,6,9,12,14-htaene 8-CHLORO-[1-PIPERAZINYL)-5H-DIBENZO[B,E][1,4]DIAZINE Clozapine Impurity C (N-Desmethyl Clozapine) N-Desmethylclozapine, 10 mM in DMSO BzATP triethylammonium salt Clozapine Impurity C（） EINECS 200-659-6 MFCD00210189 D8-N-Desmethyl Clozapine HCL Norclozapine N-Desmethyl Clozapine 2HCL in Methanol 3-chloro-6-piperazin-1-yl-5H-benzo[b][1,4]benzodiazine N-Desmethylclozapine solution Normethylclozapine N-DESMETHYLCLOZAPINE Desmethylclozapine (Norclozapine) 1.0 mg/ml in Methanol N-Demethylclozapine 5H-Dibenzo[b,e][1,4]diazine, 8-chloro-11-(1-piperazinyl) Clozapine Impurity CQ: What is Clozapine Impurity C Q: What is the CAS Number of Clozapine Impurity C Q: What is the storage condition of Clozapine Impurity C Q: What e the applications of Clozapine Impurity C |
| Description | N-Desmethylclozapine is a dengue virus inhibitor, and an agonist of δ-opioid receptor. |
|---|---|
| Related Catalog | |
| In Vitro | The IC50s of N-desmethylclozapine, fluoxetine hydrochloride, and salmeterol xinafoate in Huh-7 cells infected with DENV-2 are 1 μM, 0.38 μM, and 0.67 μM, respectively. The levels of NS3 are reduced in cells treated with all three inhibitors compared to DMSO treatment, suggesting that the inhibitors act at a stage prior to viral protein translation. N-Desmethylclozapine-treated cells show a >75% reduction in negative-strand RNA levels[1]. N-desmethylclozapine exhibits slight agonistic effects on the M1 mAChR, and agonistic properties at the 5-HT1A receptor in the cerebral cortex and hippocampus. This compound also behaves as an agonist at the δ-opioid receptor in the cerebral cortex and striatum[2]. N-desmethylclozapine (3 μM) greatly decreases the outward current in excitatory neurons, but not in inhibitory neurons. In excitatory neurons, N-desmethylclozapine alone is more effective than either clozapine alone or the combination of clozapine and N-desmethylclozapine. The effect of N-desmethylclozapine in excitatory neurons is significantly suppressed by 0.1 μM pirenzepine and 1 μM atropine. N-desmethylclozapine, but not clozapine, suppressed K+ channels via M1 receptors in excitatory cells[3]. N-desmethylclozapine leads to a decrease in TxB2 levels under unstimulated conditions as well as under TSST-1 stimulation. Clozapine, N-desmethylclozapine and CPZ possibly act on neurotransmitter systems via modulation of TxA2 or TxB2 production[5]. |
| In Vivo | N-desmethylclozapine in rat and human at M2 and M4 mAChRs underlying presynaptic modulation of GABA and glutamate release, respectively. In particular, N-desmethylclozapine maybe a M2 mAChR antagonist in the rat but has no activity at this receptor in human neocortex. However, N-desmethylclozapine has an agonistic effect at M4 mAChR in the human but no such effect in the rat neocortex[4]. |
| References |
| Density | 1.38g/cm3 |
|---|---|
| Boiling Point | 490.1ºC at 760 mmHg |
| Melting Point | 120-125°C |
| Molecular Formula | C17H17ClN4 |
| Molecular Weight | 312.79700 |
| Flash Point | 250.2ºC |
| Exact Mass | 312.11400 |
| PSA | 39.66000 |
| LogP | 3.22080 |
| Index of Refraction | 1.709 |
| Storage condition | Store at RT |
| Symbol |
GHS02, GHS06, GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H225-H301 + H311 + H331-H370 |
| Precautionary Statements | P210-P260-P280-P301 + P310-P311 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xn |
| Risk Phrases | 20/22-36/37/38 |
| Safety Phrases | S22-S36-S45 |
| RIDADR | 3249 |
| WGK Germany | 3 |
| Packaging Group | III |
| Hazard Class | 6.1(b) |
| HS Code | 2933990090 |
| Precursor 7 | |
|---|---|
| DownStream 0 | |
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |