139667-74-6
139667-74-6 structure
- Name: CGP 52432
- Chemical Name: 3-[(3,4-dichlorophenyl)methylamino]propyl-(diethoxymethyl)phosphinic acid
- CAS Number: 139667-74-6
- Molecular Formula: C15H24Cl2NO4P
- Molecular Weight: 384.23500
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel GABA Receptor
- Create Date: 2018-08-27 12:48:51
- Modify Date: 2025-08-27 17:37:10
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CGP52432 is a GABAB receptor antagonist, with an IC50 of 85 nM.
| Name | 3-[(3,4-dichlorophenyl)methylamino]propyl-(diethoxymethyl)phosphinic acid |
|---|---|
| Synonyms |
Tocris-1246
MFCD00041095 [3-[[(3,4-Dichlorophenyl)methyl]amino]propyl](diethoxymethyl)-phosphinic acid CGP52432 |
| Description | CGP52432 is a GABAB receptor antagonist, with an IC50 of 85 nM. |
|---|---|
| Related Catalog | |
| Target |
IC50: 85 nM (GABAB receptor)[1] |
| In Vitro | CGP52432 is a GABAB receptor antagonist, with an IC50 of 85 nM, 35- and 100-fold lower than at the receptors regulating somatostatin and glutamate overflow, respectively[1]. |
| In Vivo | CGP52432 (10, 30 mg/kg) shows no effect on the total arm entries and total head dips of mice on the elevated-plus maze[2]. CGP52432 (100 nmol/kg, i.v., or 1 nmol/kg, i.c.v.) abolishes the suppressive effects of GABA ( 50 μmol/kg, i.v.) on enhanced renal sympathetic nerve activity (RSNA) during ischaemia, causeing elimination of the renoprotective effects of GABA in rats[3]. |
| Animal Admin | Mice[2] Two separate cohorts of male pups are used for the study. One cohort is treated with either R(+)baclofen HCl (2 mg/kg) or with vehicle (PBS). The second cohort is treated with the GABAB receptor antagonist CGP52342 (10, 30 mg/kg) or vehicle (PBS). Drugs are freshly prepared for injection each day, by dissolution in PBS with vortexing and brief sonication. Doses of R(+)baclofen and CGP52432 are chosen to be well tolerated in adult mice. All drug treatments are given via subcutaneous injection, once daily from P14-28 in a volume of 0.05 mL[2]. |
| References |
| Density | 1.258g/cm3 |
|---|---|
| Boiling Point | 544.4ºC at 760mmHg |
| Molecular Formula | C15H24Cl2NO4P |
| Molecular Weight | 384.23500 |
| Flash Point | 283.1ºC |
| Exact Mass | 383.08200 |
| PSA | 77.60000 |
| LogP | 4.49100 |
| Vapour Pressure | 1.1E-12mmHg at 25°C |
| Index of Refraction | 1.524 |
| Storage condition | 2-8℃ |
| RIDADR | NONH for all modes of transport |
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