145915-60-2

145915-60-2 structure

Name: CGP 53353
Chemical Name: 5,6-bis(4-fluoroanilino)isoindole-1,3-dione
CAS Number: 145915-60-2
Molecular Formula: C₂₀H₁₃F₂N₃O₂
Molecular Weight: 365.33
Catalog: Signaling Pathways Cell Cycle/DNA Damage DNA/RNA Synthesis
Create Date: 2018-12-30 19:03:58
Modify Date: 2024-01-09 19:23:59
CGP-53353 (DAPH-7) is an potent PKC inhibitor with IC50s of 0.41 mM and 3.8 mM for PKCβII and PKCβI, respectively. CGP-53353 can inhibit glucose-induced cell proliferation and DNA synthesis in AoSMC and A10 cells. CGP-53353 can be used for researching atherosclerosis of diabetic patients[1].

Name	5,6-bis(4-fluoroanilino)isoindole-1,3-dione
Synonyms	CGP 53 353 DAPH 2 5,6-Bis[(4-fluorophenyl)amino]-2H-isoindole-1,3-dione DAPH 2 PKCbetaII/EGFR Inhibitor 1H-Isoindole-1,3(2H)-dione, 5,6-bis[(4-fluorophenyl)amino]- 4,5-bis(4-fluoroanilino)phthalimide 5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE Pam2CSK4 Biotin

Description	CGP-53353 (DAPH-7) is an potent PKC inhibitor with IC50s of 0.41 mM and 3.8 mM for PKCβII and PKCβI, respectively. CGP-53353 can inhibit glucose-induced cell proliferation and DNA synthesis in AoSMC and A10 cells. CGP-53353 can be used for researching atherosclerosis of diabetic patients[1].
Related Catalog	Signaling Pathways >> Epigenetics >> PKC Research Areas >> Cardiovascular Disease Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis Research Areas >> Metabolic Disease Signaling Pathways >> TGF-beta/Smad >> PKC
Target	PKCβII:0.41 mM (IC50) PKCβI:3.8 mM (IC50)
In Vitro	CGP-53353 (DAPH-7) (1 μM; 48-96 hours) inhibits glucose-induced cell proliferation in A10 cells[1]. CGP-53353 (1 μM ; 0-48 hours) inhibits the glucose-induced increase and acceleration of DNA synthesis in A10, also blocks the glucose-induced increase of S-phase cell percentage[1]. Cell Proliferation Assay Cell Line: A10 (cell proliferation induced by glucose)[1] Concentration: 1 μM Incubation Time: 48-96 hours Result: Inhibited glucose-induced cell proliferation, although A10 cell proliferation was stimulated by increasing glucose concentrations.
References	[1]. Yamamoto M, et al. Acute glucose-induced downregulation of PKC-betaII accelerates cultured VSMC proliferation. Am J Physiol Cell Physiol. 2000;279(3):C587-C595.

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