Name | ay-nh2 |
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Synonyms |
Proteinase activated receptor 4 amide,mouse
PAR-4 AGONIST AMIDE ALA-TYR-PRO-GLY-LYS-PHE-NH2 AYPGKFAMIDE PROTEASE-ACTIVATED RECEPTOR-4 AGONIST AMIDE H-ALA-TYR-PRO-GLY-LYS-PHE-NH2 AYPGKF-NH2 (Ala1)-PAR-4 (1-6) amide (mouse) PAR-4 Agonist Peptide, amide |
Description | PAR-4 Agonist Peptide, amide is a proteinase-activated receptor-4 (PAR-4) agonist, which has no effect on either PAR-1 or PAR-2 and whose effects are blocked by a PAR-4 antagonist. |
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Related Catalog | |
Target |
PAR-4[1] |
In Vivo | Compared with their BALB/cBy controls, SCID mice have a significantly greater abdominal response to colorectal distension (CRD) at the distension levels of 0.04 to 0.1 mL increasing the intensity of EMG response by 384% to 132%, respectively (P<0.01; P<0.01; P<0.01; P<0.001). PAR-4 activation effectively reverses this hypersensitivity (P<0.01, P<0.05; P<0.05; P<0.05) [1]. |
Animal Admin | Mice[1] SCID mice Male SCID mice and their BALB/cBy controls are operated as C57BL/6J mice, and on the 4th postoperative day mice receive intracolonically (IC) infusion of 100 μg PAR-4-AP or vehicle. Visceral pain measurements started 1 h following the end of infusion[1]. |
References |
Molecular Formula | C34H48N8O7 |
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Molecular Weight | 680.79400 |
Exact Mass | 680.36500 |
PSA | 252.07000 |
LogP | 2.30290 |
Storage condition | 2-8℃ |
Safety Phrases | S22-S24/25 |
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