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  • DC Chemicals Limited
  • China
  • Product Name: AY-NH2
  • Price: $3500.0/1g $950.0/100mg $1800.0/250mg
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao


352017-71-1

352017-71-1 structure
352017-71-1 structure
  • Name: (Ala1)-PAR-4 (1-6) amide (mouse) trifluoroacetate salt
  • Chemical Name: ay-nh2
  • CAS Number: 352017-71-1
  • Molecular Formula: C34H48N8O7
  • Molecular Weight: 680.79400
  • Catalog: Peptides
  • Create Date: 2017-03-20 07:19:54
  • Modify Date: 2024-01-02 08:28:39
  • PAR-4 Agonist Peptide, amide is a proteinase-activated receptor-4 (PAR-4) agonist, which has no effect on either PAR-1 or PAR-2 and whose effects are blocked by a PAR-4 antagonist.

Name ay-nh2
Synonyms Proteinase activated receptor 4 amide,mouse
PAR-4 AGONIST AMIDE
ALA-TYR-PRO-GLY-LYS-PHE-NH2
AYPGKFAMIDE
PROTEASE-ACTIVATED RECEPTOR-4 AGONIST AMIDE
H-ALA-TYR-PRO-GLY-LYS-PHE-NH2
AYPGKF-NH2
(Ala1)-PAR-4 (1-6) amide (mouse)
PAR-4 Agonist Peptide, amide
Description PAR-4 Agonist Peptide, amide is a proteinase-activated receptor-4 (PAR-4) agonist, which has no effect on either PAR-1 or PAR-2 and whose effects are blocked by a PAR-4 antagonist.
Related Catalog
Target

PAR-4[1]

In Vivo Compared with their BALB/cBy controls, SCID mice have a significantly greater abdominal response to colorectal distension (CRD) at the distension levels of 0.04 to 0.1 mL increasing the intensity of EMG response by 384% to 132%, respectively (P<0.01; P<0.01; P<0.01; P<0.001). PAR-4 activation effectively reverses this hypersensitivity (P<0.01, P<0.05; P<0.05; P<0.05) [1].
Animal Admin Mice[1] SCID mice Male SCID mice and their BALB/cBy controls are operated as C57BL/6J mice, and on the 4th postoperative day mice receive intracolonically (IC) infusion of 100 μg PAR-4-AP or vehicle. Visceral pain measurements started 1 h following the end of infusion[1].
References

[1]. Annaházi A, et al. Proteinase-activated receptor-4 evoked colorectal analgesia in mice: an endogenously activatedfeed-back loop in visceral inflammatory pain. Neurogastroenterol Motil. 2012 Jan;24(1):76-85, e13.

Molecular Formula C34H48N8O7
Molecular Weight 680.79400
Exact Mass 680.36500
PSA 252.07000
LogP 2.30290
Storage condition 2-8℃
Safety Phrases S22-S24/25