Shanghai Nianxing Industrial Co., Ltd
China
Product Name: BW-A 78U
Price:
Purity: 98.0%
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ShangHai DC Chemicals Co.,Ltd
China
Product Name: BW-A 78U
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
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DC Chemicals Limited
China
Product Name: BW-A 78U
Price: $750.0/100mg $1300.0/250mg $2600.0/1g
Purity: 98.0%
Stocking Period: 3 Day
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 9-(2-fluorobenzyl)-6-(methylamino)-9H-purine
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Purity: 98.0%
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101155-02-6

101155-02-6 structure

101155-02-6 structure

Name: BW-A 78U
Chemical Name: 9-[(2-fluorophenyl)methyl]-N-methylpurin-6-amine
CAS Number: 101155-02-6
Molecular Formula: C₁₃H₁₂FN₅
Molecular Weight: 257.26600
Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphodiesterase (PDE)
Create Date: 2016-08-31 11:19:20
Modify Date: 2024-01-12 11:47:55
BW-A 78U is a PDE4 inhibitor with an IC50 of 3 μM.

Name	9-[(2-fluorophenyl)methyl]-N-methylpurin-6-amine
Synonyms	bw-a 78u

Description	BW-A 78U is a PDE4 inhibitor with an IC50 of 3 μM.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE) Research Areas >> Inflammation/Immunology
Target	PDE4:3 μM (IC50)
In Vitro	BW-A 78U is a PDE4 inhibitor with an IC50 of 3 μM. BW-A 78U fails to significantly inhibit arachidonate release. BW-A 78U is ineffective to inhibit the lipopolysaccharide (LPS)-induced TNF-α release[1].
Cell Assay	Mononuclear cells are incubated for 30 min with BW-A 78U at the concentration of 10 nM to 10 μM. The cells are then stimulated with lipopolysaccharide (10 μg/mL) overnight at 37°C in an atmosphere of 5% CO2 at 100% humidity. Cell-free supernatants are collected, centrifuged (2000 g), and stored frozen at -20°C before TNF-α determination. TNF-α concentrations in cell culture supernatants are determined by specific ELISA using a commercial kit. Sensitivity of the assay is 1 pg/mL. The absorbance at 450 nm is assessed with an ELISA reader[1].
References	[1]. Boichot E, et al. Anti-inflammatory activities of a new series of selective phosphodiesterase 4 inhibitors derivedfrom 9-benzyladenine. J Pharmacol Exp Ther. 2000 Feb;292(2):647-53.

Density	1.36g/cm3
Boiling Point	477.9ºC at 760mmHg
Molecular Formula	C₁₃H₁₂FN₅
Molecular Weight	257.26600
Flash Point	242.8ºC
Exact Mass	257.10800
PSA	55.63000
LogP	2.12840
Vapour Pressure	2.69E-09mmHg at 25°C
Storage condition	2-8℃

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UO7440800

CHEMICAL NAME :: 9H-Purin-6-amine, 9-((2-fluorophenyl)methyl)-N-methyl-

CAS REGISTRY NUMBER :: 101155-02-6

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C13-H12-F-N5

MOLECULAR WEIGHT :: 257.30

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Behavioral - ataxia

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 29,1133,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JHTCAD Journal of Heterocyclic Chemistry. (Hetero Corporation, POB 16000 MH, Tampa, FL 33687) Vol.1- 1964- Volume(issue)/page/year: 25,1255,1988

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 120 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JHTCAD Journal of Heterocyclic Chemistry. (Hetero Corporation, POB 16000 MH, Tampa, FL 33687) Vol.1- 1964- Volume(issue)/page/year: 25,1255,1988