286942-97-0

286942-97-0 structure

Name: Ezatiostat (hydrochloride)
Chemical Name: ethyl (2S)-2-amino-5-[[(2R)-3-benzylsulfanyl-1-[[(1R)-2-ethoxy-2-oxo-1-phenylethyl]amino]-1-oxopropan-2-yl]amino]-5-oxopentanoate,hydrochloride
CAS Number: 286942-97-0
Molecular Formula: C₂₇H₃₆ClN₃O₆S
Molecular Weight: 566.109
Catalog: Biochemical Amino acids and their derivatives Glycine derivatives
Create Date: 2018-04-22 08:00:00
Modify Date: 2024-01-17 20:21:13
Ezatiostat hydrochloride is a glutathione analog inhibitor of glutathione S-transferase P1-1 (GSTP1-1).

Name	ethyl (2S)-2-amino-5-[[(2R)-3-benzylsulfanyl-1-[[(1R)-2-ethoxy-2-oxo-1-phenylethyl]amino]-1-oxopropan-2-yl]amino]-5-oxopentanoate,hydrochloride
Synonyms	ethyl (2R)-[(4S)-4-amino-5-ethoxy-5-oxopentanoyl]-S-benzyl-L-cysteinyl-2- phenylglycinate hydrochloride Ethyl (2S)-2-amino-5-{[(2R)-3-(benzylsulfanyl)-1-{[(1R)-2-ethoxy-2-oxo-1-phenylethyl]amino}-1-oxo-2-propanyl]amino}-5-oxopentanoate hydrochloride (1:1) Ezatiostat hydrochloride Ezatiostat HCl TLK199 ethyl (2S)-2-amino-5-[[(2R)-3-benzylsulfanyl-1-[[(1R)-2-ethoxy-2-oxo-1-phenylethyl]amino]-1-oxopropan-2-yl] amino]-5-oxopentanoate hydrochloride TER199 Glycine, L-γ-glutamyl-S-(phenylmethyl)-L-cysteinyl-2-phenyl-, diethyl ester, monohydrochloride, (2R)- Ezatiostat hydrochloride (USAN) Telintra(R) L-gamma-Glutamyl-S-(phenylmethyl)-L-cysteinyl-2-phenylglycinediethylestermonohydrochloride Ezatiostat (hydrochloride)

Description	Ezatiostat hydrochloride is a glutathione analog inhibitor of glutathione S-transferase P1-1 (GSTP1-1).
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Gutathione S-transferase Research Areas >> Cancer
In Vitro	Ezatiostat causes dissociation of the enzyme from the jun-N-terminal kinase/c-Jun (JNK/JUN) complex, leading to JNK activation by phosphorylation. The therapeutic action of ezatiostat appears to include both proliferation of normal myeloid progenitors as well as apoptosis of the malignant clone[1].
References	[1]. Galili N, et al. Prediction of response to therapy with ezatiostat in lower risk myelodysplastic syndrome. J Hematol Oncol. 2012 May 6;5:20.