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1758-80-1

1758-80-1 structure
1758-80-1 structure
  • Name: H-Dab.HBr
  • Chemical Name: L-2,4-diaminobutyric acid
  • CAS Number: 1758-80-1
  • Molecular Formula: C4H10N2O2
  • Molecular Weight: 118.13
  • Catalog: Biochemical Amino acids and their derivatives Amino acid salt
  • Create Date: 2018-09-16 09:06:25
  • Modify Date: 2024-01-03 06:35:31
  • L-DABA (L-2,4-Diaminobutyric acid) is a week GABA transaminase inhibitor with an IC50 of larger than 500 μM; exhibits antitumor activity in vivo and in vitro.
Name L-2,4-diaminobutyric acid
Synonyms L-DAB HBR
MFCD07368664
L-2,4-Diaminobutyric acid hydrobromine
(2S)-2,4-Diaminobutanoic acid hydrobromide (1:1)
Butanoic acid, 2,4-diamino-, (2S)-, hydrobromide (1:1)
L-DABA
L-Dab.HBr
H-Dab.HBr
Description L-DABA (L-2,4-Diaminobutyric acid) is a week GABA transaminase inhibitor with an IC50 of larger than 500 μM; exhibits antitumor activity in vivo and in vitro.
Related Catalog
Target

Human Endogenous Metabolite
In Vitro The tumor cells are irreversibly and totally damaged by incubation with 10 mM L-2,4-Diaminobutyric acid for 24 h at 37°C. The cell-destructive effect by L-DABA is probably due to an osmotic lysis induced by the non-saturated intracellular accumulation of L-DABA. The harmful effect of L-DABA could be abolished by concomitant incubation with L-alanine and L-methionine[1]. Kinetic studies indicates that L-DABA is a non-linear, non-competitive inhibitor of GABA transaminase activity. The L-DABA-induced elevation of GABA levels parallels the inhibition of GABA transaminase activity[2]. L-2,4-Diaminobutyric acid, an amino acid analogue, produceS a cytolytic effect with a human glioma cell line, SKMG-1, and normal human fibroblasts. The concentrations of L-DABA necessary to reduce the cell count to 50% of control following a 24-h incubation at 37°C are 12.5 mM for the human fibroblasts and 20 mM for the glioma cell line[3].
In Vivo Treatment with L-DABA results in 43.4% reduction of tumor growth[1]. L-DABA is a more effective inhibitor of GABA transaminase in vivo than in vitro[2].
Animal Admin Mice: Male Sprague Dawley rats (150-200g) are used in the study. LDABA is dissolved in 09.% saline and diluted in appropriate medium. L-DABA is administered intraperitoneally at a dose of 764 mg/kg in a volume of 4 mL/kg in acute studies. Chronically treated rats receives daily intraperitoneally injections (2.5mM/kg in saline) for 3 days. Mice are sacrificed and the brain regions are dissected for analysis[2].
References

[1]. Ronquist G, et al. Antitumor activity of L-2,4 diaminobuturic acid against mouse fibrosarcoma cells in vitro and in vivo. J Cancer Res Clin Oncol. 1980;96(3):259-68.

[2]. Beart PM, et al. l-2,4-Diaminobutyric acid and the GABA system. Neurosci Lett. 1977 Jul;5(3-4):193-8.

[3]. Panasci L, et al. The cytolytic effect of L-2,4 diaminobutyric acid with malignant glioma cells and fibroblasts. Cancer Chemother Pharmacol. 1988;21(2):143-4.
Density 1.218 g/cm3
Boiling Point 321ºC at 760 mmHg
Molecular Formula C4H10N2O2
Molecular Weight 118.13
Flash Point 147.9ºC
PSA 89.34000
LogP 1.10580
Vapour Pressure 6.36E-05mmHg at 25°C
Index of Refraction 1.513
Hazard Codes Xi
HS Code 2922499990
HS Code 2922499990
Summary HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

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title: CAS No. 1758-80-1 | Chemsrc address: https://m.chemsrc.com/en/baike/1107334.html

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