Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Perylo[1,12-def]-1,3-dioxepin-5,11-dione,6,12-dihydroxy-8,9-bis[(2R)-2-hydroxypropyl]-7,10-dimethoxy-, (13bR)-
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Purity: 98.0%
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35082-49-6

35082-49-6 structure

Name: Cercosporin
Chemical Name: cercosporin, pure
CAS Number: 35082-49-6
Molecular Formula: C₂₉H₂₆O₁₀
Molecular Weight: 534.51100
Catalog: Signaling Pathways Epigenetics PKC
Create Date: 2016-08-29 01:44:42
Modify Date: 2026-07-01 20:17:07
Cercosporin is produced by a plant pathogen, Cercosporakikuchii, and the elsinochromes, pigments of the elsinoe family of fungi. Cercosporin is a potent photosensitizer with a short activation wavelength, mostly suitable for superficial photodynamic therapy (PDT) treatments, especially when it is necessary to avoid perforations[1].Cercosporin contains the perylenequinone structural features necessary to PKC activity with an IC50 of 0.6-1.3 μM[2].

Name	cercosporin, pure
Synonyms	CGP-049090 (CGP049090 CGP049090, NSC CERCOSPORIN FROM CERCOSPORA HAYII 6,12-Dihydroxy-8,9-bis(2-hydroxypropyl)-7,10-dimethoxyperylo[1,12-def]-1,3-dioxin-5,11-dione cercosporin from cercospora hayii cercosporin CERCOSPORIN CGP-049090 Perylo[1,12-def]-1,3-dioxin-5,11-dione, 6,12-dihydroxy-8,9-bis[(2R)-2-hydroxypropyl]-7,10-dimethoxy-, (13bR) (+)-Cercosporin 6,12-Dihydroxy-7,10-dimethoxy-8,9-bis[(R)-2-hydroxypropyl]perylo[1,12-def]-1,3-dioxin-5,11-dione Cercosporin, PKC inhibitor

Description	Cercosporin is produced by a plant pathogen, Cercosporakikuchii, and the elsinochromes, pigments of the elsinoe family of fungi. Cercosporin is a potent photosensitizer with a short activation wavelength, mostly suitable for superficial photodynamic therapy (PDT) treatments, especially when it is necessary to avoid perforations[1].Cercosporin contains the perylenequinone structural features necessary to PKC activity with an IC50 of 0.6-1.3 μM[2].
Related Catalog	Signaling Pathways >> Epigenetics >> PKC Research Areas >> Cancer Signaling Pathways >> TGF-beta/Smad >> PKC
Target	IC50: 0.6-1.3 μM (PKC)[2]
In Vitro	Cercosporin (0.8-8.0 μM; 30 s, 60 s, 90 s, 120 s) photodynamic therapy (PDT) effect is stronger in T98G cells than in U87 or MCF7 cells, the LD50 value for the T98G cells (0.14 J cm2) is much less than the LD50 value for MCF-7 and U87 cell lines (0.26 and 0.24 J cm2, respectively)[1]. Cercosporin (0-3 μΜ; 24 hours) interplays with copper results in a synergistic cytotoxicity in MCF7 and T98G cells, that is, S(CuSO4 + Cerco) ≪ S(CuSO4) x S(Cerco), barely has an additive effect in U87 cells[1]. Cell Viability Assay[1] Cell Line: Human GBM cell lines, T98G and U87; Breast carcinoma cell line, MCF-7 Concentration: 0 μM, 1 μM, 2 μM, 3 μM Incubation Time: 24 hours Result: Exhibited a synergistic cytotoxicity with copper only in the most respiratory cell lines (MCF-7 and T98G).
References	[1]. Mastrangelopoulou M, et al. Cytotoxic and Photocytotoxic Effects of Cercosporin on Human Tumor Cell Lines. Photochem Photobiol. 2019 Jan;95(1):387-396. [2]. Morgan BJ, et al. Design, synthesis, and investigation of protein kinase C inhibitors: total syntheses of (+)-calphostin D, (+)-phleichrome, cercosporin, and new photoactive perylenequinones. J Am Chem Soc. 2009 Jul 8;131(26):9413-25.

Density	1.59g/cm3
Boiling Point	886.9ºC at 760mmHg
Molecular Formula	C₂₉H₂₆O₁₀
Molecular Weight	534.51100
Flash Point	299ºC
Exact Mass	534.15300
PSA	151.98000
LogP	3.56450
Index of Refraction	1.754

Hazard Codes	Xn: Harmful;
RIDADR	NONH for all modes of transport

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