6964-62-1
6964-62-1 structure
- Name: NSC 66811
- Chemical Name: 7-[anilino(phenyl)methyl]-2-methylquinolin-8-ol
- CAS Number: 6964-62-1
- Molecular Formula: C23H20N2O
- Molecular Weight: 340.418
- Catalog: Signaling Pathways Apoptosis MDM-2/p53
- Create Date: 2016-10-09 18:35:18
- Modify Date: 2024-01-02 21:51:19
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NSC 66811 is a MDM2-p53 inhibitor, with a Ki of 120 nM for binding to MDM2[1].
| Name | 7-[anilino(phenyl)methyl]-2-methylquinolin-8-ol |
|---|---|
| Synonyms |
(2-methyl-7-[phenyl(phenylamino)methyl]-8-quinolinol)
7-[Anilino(phenyl)methyl]-2-methyl-8-quinolinol 7-(anilino(phenyl)methyl)-2-methyl-8-quinolinol 2-methyl-7-[phenyl(phenylamino)methyl]quinolin-8-ol 7-[Anilino(phenyl)methyl]-2-methylquinolin-8-ol 8-Quinolinol, 2-methyl-7-[phenyl(phenylamino)methyl]- 7-(Anilino(phenyl)-methyl)-2-methyl-8-quinolinol |
| Description | NSC 66811 is a MDM2-p53 inhibitor, with a Ki of 120 nM for binding to MDM2[1]. |
|---|---|
| Related Catalog | |
| In Vitro | NSC 66811 (0, 5, 10, 20 μM) dose-dependently induces the accumulation of p53, MDM2, and p21cip1/waf due to the functional activation of p53[1]. Western Blot Analysis[1] Cell Line: HCT-116 (p53+/+ and p53-/-) cells[1]. Concentration: 0, 5, 10, 20 μM. Incubation Time: 48 h. Result: Dose-dependently induced the accumulation of p53, MDM2, and p21cip1/waf proteins in the HCT-116 human colon cancer cell line with wild-type p53. Had no effect on the levels for p53, MDM2, and p21cip1/waf protein in the isogenic HCT-116 p53-/- cell line. |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 529.5±45.0 °C at 760 mmHg |
| Melting Point | 145 °C |
| Molecular Formula | C23H20N2O |
| Molecular Weight | 340.418 |
| Flash Point | 274.0±28.7 °C |
| Exact Mass | 340.157562 |
| PSA | 45.15000 |
| LogP | 4.73 |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
| Index of Refraction | 1.708 |
|
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6964-62-1 |
| Literature: Journal of Organic Chemistry, , vol. 21, p. 692 |
