NSC 66811
Modify Date: 2024-01-02 21:51:19
NSC 66811 structure
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Common Name | NSC 66811 | ||
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| CAS Number | 6964-62-1 | Molecular Weight | 340.418 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 529.5±45.0 °C at 760 mmHg | |
| Molecular Formula | C23H20N2O | Melting Point | 145 °C | |
| MSDS | N/A | Flash Point | 274.0±28.7 °C | |
Use of NSC 66811NSC 66811 is a MDM2-p53 inhibitor, with a Ki of 120 nM for binding to MDM2[1]. |
| Name | 7-[anilino(phenyl)methyl]-2-methylquinolin-8-ol |
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| Synonym | More Synonyms |
| Description | NSC 66811 is a MDM2-p53 inhibitor, with a Ki of 120 nM for binding to MDM2[1]. |
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| Related Catalog | |
| In Vitro | NSC 66811 (0, 5, 10, 20 μM) dose-dependently induces the accumulation of p53, MDM2, and p21cip1/waf due to the functional activation of p53[1]. Western Blot Analysis[1] Cell Line: HCT-116 (p53+/+ and p53-/-) cells[1]. Concentration: 0, 5, 10, 20 μM. Incubation Time: 48 h. Result: Dose-dependently induced the accumulation of p53, MDM2, and p21cip1/waf proteins in the HCT-116 human colon cancer cell line with wild-type p53. Had no effect on the levels for p53, MDM2, and p21cip1/waf protein in the isogenic HCT-116 p53-/- cell line. |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 529.5±45.0 °C at 760 mmHg |
| Melting Point | 145 °C |
| Molecular Formula | C23H20N2O |
| Molecular Weight | 340.418 |
| Flash Point | 274.0±28.7 °C |
| Exact Mass | 340.157562 |
| PSA | 45.15000 |
| LogP | 4.73 |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
| Index of Refraction | 1.708 |
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~%
NSC 66811 CAS#:6964-62-1 |
| Literature: Journal of Organic Chemistry, , vol. 21, p. 692 |
| Precursor 2 | |
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| DownStream 0 | |
| (2-methyl-7-[phenyl(phenylamino)methyl]-8-quinolinol) |
| 7-[Anilino(phenyl)methyl]-2-methyl-8-quinolinol |
| 7-(anilino(phenyl)methyl)-2-methyl-8-quinolinol |
| 2-methyl-7-[phenyl(phenylamino)methyl]quinolin-8-ol |
| 7-[Anilino(phenyl)methyl]-2-methylquinolin-8-ol |
| 8-Quinolinol, 2-methyl-7-[phenyl(phenylamino)methyl]- |
| 7-(Anilino(phenyl)-methyl)-2-methyl-8-quinolinol |