32795-44-1

32795-44-1 structure

Name: N-Acetylprocainamide
Chemical Name: N-acetylprocainamide
CAS Number: 32795-44-1
Molecular Formula: C₁₅H₂₃N₃O₂
Molecular Weight: 277.36200
Catalog: API Circulatory system medication Antiarrhythmic drug
Create Date: 2018-07-25 17:42:38
Modify Date: 2025-08-26 19:42:26
N-Acetylprocainamide is a class III antiarrhythmic, which blocks K+ channels.

Name	N-acetylprocainamide
Synonyms	NAPA 4-acetamido-N-(2-diethylaminoethyl)benzamide Acecainide [INN] MFCD00009052 4-acetamido-N-[2-(diethylamino)ethyl]benzamide N-Acetyloprokainamid Acecainidum Acekainid N-Acetylnovocainamide Acekainid [Polish] Acecainide 4-acetylamino-N-(2-diethylamino-ethyl)-benzamide Acecainida N-Acetylprocainamide

Description	N-Acetylprocainamide is a class III antiarrhythmic, which blocks K+ channels.
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel Research Areas >> Cardiovascular Disease
Target	K+ channel[1]
In Vitro	N-Acetylprocainamide is a K+ blocker. N-Acetylprocainamide decreases the tensions induced by K+ and methacholine. The pIC50 values for N-acetylprocainamide against the contractions induced by 0.3 and 1 μM methacholine are 2.80 ± 0.03 and 2.65 ± 0.02, respectively. And such a relaxant effect of N-Acetylprocainamide is inhibited by K+ channel blockers[1]. N-Acetylprocainamide shows no effect on Na+ absorption or Cl- secretion[2].
References	[1]. Nakahara T, et al. Role of K+ channels in N-acetylprocainamide-induced relaxation of bovine tracheal smooth muscle. Eur J Pharmacol. 2001 Mar 9;415(1):73-8. [2]. Plass H, et al. Class I antiarrhythmics inhibit Na+ absorption and Cl- secretion in rabbit descending colon epithelium. Naunyn Schmiedebergs Arch Pharmacol. 2005 Jun;371(6):492-9.

Density	1.097g/cm3
Boiling Point	500ºC at 760mmHg
Melting Point	138-140ºC(lit.)
Molecular Formula	C₁₅H₂₃N₃O₂
Molecular Weight	277.36200
Flash Point	256.2ºC
Exact Mass	277.17900
PSA	61.44000
LogP	2.18050
Storage condition	-20°C
Water Solubility	soluble1%, clear, colorless to faintly yellow (1N HCl)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AE1974350

CHEMICAL NAME :: Acetanilide, 4'-((2-(diethylamino)ethyl)carbamoyl)-

CAS REGISTRY NUMBER :: 32795-44-1

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C15-H23-N3-O2

MOLECULAR WEIGHT :: 277.41

WISWESSER LINE NOTATION :: 2N2&2MVR DMV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 380 mg/kg

TOXIC EFFECTS :: Cardiac - other changes

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 169,156,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3173 No. of Facilities: 71 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 758 (estimated) No. of Female Employees: 361 (estimated)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	36/37/38
Safety Phrases	26-36
RIDADR	UN 3249
WGK Germany	3
RTECS	AE1974350
Packaging Group	III
Hazard Class	6.1(b)
HS Code	2924299090

201230-82-2

103-88-8

100-36-7

~75%

32795-44-1

Literature: Dang, Tuan T.; Zhu, Yinghuai; Ngiam, Joyce S. Y.; Ghosh, Subhash C.; Chen, Anqi; Seayad, Abdul M. ACS Catalysis, 2013 , vol. 3, # 6 p. 1406 - 1410

122-85-0

100-36-7

~80%

32795-44-1

Literature: Ghosh, Subhash Chandra; Ngiam, Joyce S. Y.; Seayad, Abdul M.; Tuan, Dang Thanh; Chai, Christina L. L.; Chen, Anqi Journal of Organic Chemistry, 2012 , vol. 77, # 18 p. 8007 - 8015,9 Title/Abstract Full Text Show Details Ghosh, Subhash Chandra; Ngiam, Joyce S.Y.; Seayad, Abdul M.; Tuan, Dang Thanh; Chai, Christina L.L.; Chen, Anqi Journal of Organic Chemistry, 2012 , vol. 77, # 18 p. 8007 - 8015

614-39-1

75-36-5

~19%

32795-44-1

Literature: CORUS PHARMA Patent: WO2005/25498 A2, 2005 ; Location in patent: Page/Page column 21 ;

Precursor 6
201230-82-2 103-88-8 100-36-7 122-85-0
614-39-1 75-36-5
DownStream 0

HS Code	2924299090
Summary	2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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