Name | N-acetylprocainamide |
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Synonyms |
NAPA
4-acetamido-N-(2-diethylaminoethyl)benzamide Acecainide [INN] MFCD00009052 4-acetamido-N-[2-(diethylamino)ethyl]benzamide N-Acetyloprokainamid Acecainidum Acekainid N-Acetylnovocainamide Acekainid [Polish] Acecainide 4-acetylamino-N-(2-diethylamino-ethyl)-benzamide Acecainida N-Acetylprocainamide |
Description | N-Acetylprocainamide is a class III antiarrhythmic, which blocks K+ channels. |
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Related Catalog | |
Target |
K+ channel[1] |
In Vitro | N-Acetylprocainamide is a K+ blocker. N-Acetylprocainamide decreases the tensions induced by K+ and methacholine. The pIC50 values for N-acetylprocainamide against the contractions induced by 0.3 and 1 μM methacholine are 2.80 ± 0.03 and 2.65 ± 0.02, respectively. And such a relaxant effect of N-Acetylprocainamide is inhibited by K+ channel blockers[1]. N-Acetylprocainamide shows no effect on Na+ absorption or Cl- secretion[2]. |
References |
Density | 1.097g/cm3 |
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Boiling Point | 500ºC at 760mmHg |
Melting Point | 138-140ºC(lit.) |
Molecular Formula | C15H23N3O2 |
Molecular Weight | 277.36200 |
Flash Point | 256.2ºC |
Exact Mass | 277.17900 |
PSA | 61.44000 |
LogP | 2.18050 |
Storage condition | -20°C |
Water Solubility | soluble1%, clear, colorless to faintly yellow (1N HCl) |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
Symbol |
GHS07 |
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Signal Word | Warning |
Hazard Statements | H315-H319-H335 |
Precautionary Statements | P261-P305 + P351 + P338 |
Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
Hazard Codes | Xi: Irritant; |
Risk Phrases | 36/37/38 |
Safety Phrases | 26-36 |
RIDADR | UN 3249 |
WGK Germany | 3 |
RTECS | AE1974350 |
Packaging Group | III |
Hazard Class | 6.1(b) |
HS Code | 2924299090 |
~75% 32795-44-1 |
Literature: Dang, Tuan T.; Zhu, Yinghuai; Ngiam, Joyce S. Y.; Ghosh, Subhash C.; Chen, Anqi; Seayad, Abdul M. ACS Catalysis, 2013 , vol. 3, # 6 p. 1406 - 1410 |
~80% 32795-44-1 |
Literature: Ghosh, Subhash Chandra; Ngiam, Joyce S. Y.; Seayad, Abdul M.; Tuan, Dang Thanh; Chai, Christina L. L.; Chen, Anqi Journal of Organic Chemistry, 2012 , vol. 77, # 18 p. 8007 - 8015,9 Title/Abstract Full Text Show Details Ghosh, Subhash Chandra; Ngiam, Joyce S.Y.; Seayad, Abdul M.; Tuan, Dang Thanh; Chai, Christina L.L.; Chen, Anqi Journal of Organic Chemistry, 2012 , vol. 77, # 18 p. 8007 - 8015 |
~19% 32795-44-1 |
Literature: CORUS PHARMA Patent: WO2005/25498 A2, 2005 ; Location in patent: Page/Page column 21 ; |
HS Code | 2924299090 |
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Summary | 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |