N-Acetylprocainamide

Modify Date: 2024-01-04 11:31:52

N-Acetylprocainamide structure	Common Name	N-Acetylprocainamide
	CAS Number	32795-44-1	Molecular Weight	277.36200
	Density	1.097g/cm3	Boiling Point	500ºC at 760mmHg
	Molecular Formula	C₁₅H₂₃N₃O₂	Melting Point	138-140ºC(lit.)
	MSDS	Chinese USA	Flash Point	256.2ºC
	Symbol	GHS07	Signal Word	Warning

Use of N-Acetylprocainamide

N-Acetylprocainamide is a class III antiarrhythmic, which blocks K+ channels.

Name	N-acetylprocainamide
Synonym	More Synonyms

Description	N-Acetylprocainamide is a class III antiarrhythmic, which blocks K+ channels.
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel Research Areas >> Cardiovascular Disease
Target	K+ channel[1]
In Vitro	N-Acetylprocainamide is a K+ blocker. N-Acetylprocainamide decreases the tensions induced by K+ and methacholine. The pIC50 values for N-acetylprocainamide against the contractions induced by 0.3 and 1 μM methacholine are 2.80 ± 0.03 and 2.65 ± 0.02, respectively. And such a relaxant effect of N-Acetylprocainamide is inhibited by K+ channel blockers[1]. N-Acetylprocainamide shows no effect on Na+ absorption or Cl- secretion[2].
References	[1]. Nakahara T, et al. Role of K+ channels in N-acetylprocainamide-induced relaxation of bovine tracheal smooth muscle. Eur J Pharmacol. 2001 Mar 9;415(1):73-8. [2]. Plass H, et al. Class I antiarrhythmics inhibit Na+ absorption and Cl- secretion in rabbit descending colon epithelium. Naunyn Schmiedebergs Arch Pharmacol. 2005 Jun;371(6):492-9.

Density	1.097g/cm3
Boiling Point	500ºC at 760mmHg
Melting Point	138-140ºC(lit.)
Molecular Formula	C₁₅H₂₃N₃O₂
Molecular Weight	277.36200
Flash Point	256.2ºC
Exact Mass	277.17900
PSA	61.44000
LogP	2.18050
Storage condition	-20°C
Water Solubility	soluble1%, clear, colorless to faintly yellow (1N HCl)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AE1974350

CHEMICAL NAME :: Acetanilide, 4'-((2-(diethylamino)ethyl)carbamoyl)-

CAS REGISTRY NUMBER :: 32795-44-1

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C15-H23-N3-O2

MOLECULAR WEIGHT :: 277.41

WISWESSER LINE NOTATION :: 2N2&2MVR DMV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 380 mg/kg

TOXIC EFFECTS :: Cardiac - other changes

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 169,156,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3173 No. of Facilities: 71 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 758 (estimated) No. of Female Employees: 361 (estimated)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	36/37/38
Safety Phrases	26-36
RIDADR	UN 3249
WGK Germany	3
RTECS	AE1974350
Packaging Group	III
Hazard Class	6.1(b)
HS Code	2924299090

carbon monoxide

CAS#:201230-82-2

4-Bromoacetanilide

CAS#:103-88-8

2-aminoethyldie...

CAS#:100-36-7

~75%

N-Acetylprocainamide

CAS#:32795-44-1

Literature: Dang, Tuan T.; Zhu, Yinghuai; Ngiam, Joyce S. Y.; Ghosh, Subhash C.; Chen, Anqi; Seayad, Abdul M. ACS Catalysis, 2013 , vol. 3, # 6 p. 1406 - 1410

4-Acetamidobenz...

CAS#:122-85-0

2-aminoethyldie...

CAS#:100-36-7

~80%

N-Acetylprocainamide

CAS#:32795-44-1

Literature: Ghosh, Subhash Chandra; Ngiam, Joyce S. Y.; Seayad, Abdul M.; Tuan, Dang Thanh; Chai, Christina L. L.; Chen, Anqi Journal of Organic Chemistry, 2012 , vol. 77, # 18 p. 8007 - 8015,9 Title/Abstract Full Text Show Details Ghosh, Subhash Chandra; Ngiam, Joyce S.Y.; Seayad, Abdul M.; Tuan, Dang Thanh; Chai, Christina L.L.; Chen, Anqi Journal of Organic Chemistry, 2012 , vol. 77, # 18 p. 8007 - 8015

ProcainaMide hy...

CAS#:614-39-1

Acetyl chloride

CAS#:75-36-5

~19%

N-Acetylprocainamide

CAS#:32795-44-1

Literature: CORUS PHARMA Patent: WO2005/25498 A2, 2005 ; Location in patent: Page/Page column 21 ;

Precursor 6
CAS#:201230-82-2 carbon monoxide CAS#:103-88-8 4-Bromoacetanilide CAS#:100-36-7 2-aminoethyldie... CAS#:122-85-0 4-Acetamidobenz...
CAS#:614-39-1 ProcainaMide hy... CAS#:75-36-5 Acetyl chloride
DownStream 0

HS Code	2924299090
Summary	2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Drug-herb interaction: effect of St John's wort on bioavailability and metabolism of procainamide in mice.

Arch. Pathol. Lab. Med. 131(7) , 1094-8, (2007)

St John's wort induces the activity of the cytochrome P450 enzyme system causing treatment failure because of increased metabolism of many drugs. Procainamide is metabolized by a different pathway to ...

Application of computer-assisted radiotelemetry in the pharmacokinetic and pharmacodynamic modeling of procainamide and N-acetylprocainamide.

J. Pharm. Sci. 85(6) , 595-9, (1996)

The cardiovascular pharmacodynamics (PD) of procainamide and N-acetylprocainamide have not been well characterized in small rodents without the presence of anesthesia or restraint. This study was unde...

The discordant influences of infarct healing on the electrophysiologic effects of procainamide and N-acetylprocainamide.

J. Pharmacol. Exp. Ther. 273(1) , 315-9, (1995)

Ischemic zone refractoriness and conduction delay respond differently to infarct healing and, hypothetically, may exert discordant influences on the electrophysiologic action of different classes of a...

NAPA

4-acetamido-N-(2-diethylaminoethyl)benzamide

Acecainide [INN]

MFCD00009052

4-acetamido-N-[2-(diethylamino)ethyl]benzamide

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Acecainidum

Acekainid

N-Acetylnovocainamide

Acekainid [Polish]

Acecainide

4-acetylamino-N-(2-diethylamino-ethyl)-benzamide

Acecainida

N-Acetylprocainamide

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N-Acetylprocainamide

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