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1149-99-1

1149-99-1 structure

1149-99-1 structure

Name: Illudin S
Chemical Name: Illudin S
CAS Number: 1149-99-1
Molecular Formula: C₁₅H₂₀O₄
Molecular Weight: 264.31700
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2017-08-05 01:43:38
Modify Date: 2026-07-09 23:22:07
Illudin S is a sesquiterpene toxin with strong anti-tumour and antiviral activities. Illudin S has genotoxic activities[1][2][3].

Name	Illudin S
Synonyms	(2'S,3'R,6'R)-3',6'-dihydroxy-2'-(hydroxymethyl)-2',4',6'-trimethyl-2',3',6',7'-tetrahydrospiro[cyclopropane-1,5'-inden]-7'-one (1R,2S,5R)-1,5-dihydroxy-2-(hydroxymethyl)-2,5,7-trimethylspiro[1H-indene-6,1'-cyclopropane]-4-one Lunamycin (2'S,3'R,6'R)-2',3'-Dihydro-3',6'-dihydroxy-2'-hydroxymethyl-2',4',6'-trimethylspiro[cyclopropane-1,5'-[5H]inden]-7'(6'H)-one Spiro[cyclopropane-1,5'-[5H]inden]-7'(6'H)-one, 2',3'-dihydro-3',6'-dihydroxy-2'-(hydroxymethyl)-2',4',6'-trimethyl-, (2'S,3'R,6'R) Illudin llludin S illudin S NSC-626369 Illudine S Lampterol Illusin S

Description	Illudin S is a sesquiterpene toxin with strong anti-tumour and antiviral activities. Illudin S has genotoxic activities[1][2][3].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Research Areas >> Infection Signaling Pathways >> Cell Cycle/DNA Damage >> DNA Alkylator/Crosslinker
In Vitro	Illudin S (0-0.26 nM; 24-72 hours) shows cytotoxicity in human fibroblasts[2]. Cell Viability Assay[2] Cell Line: human fibroblasts Concentration: 0-0.26 nM Incubation Time: 24 hours, 72 hours Result: Decreased cell survival.
References	[1]. Hansruedi Glatt, et al. Sulfotransferase-independent genotoxicity of illudin S and its acylfulvene derivatives in bacterial and mammalian cells. Arch Toxicol . 2014 Jan;88(1):161-9. [2]. Nicolaas G J Jaspers, et al. Anti-tumour compounds illudin S and Irofulven induce DNA lesions ignored by global repair and exclusively processed by transcription- and replication-coupled repair pathways. DNA Repair (Amst). 2002 Dec 5;1(12):1027-38. [3]. Illudin S, the sole antiviral compound in mature fruiting bodies of Omphalotus illudens

Density	1.34g/cm3
Boiling Point	509.6ºC at 760mmHg
Molecular Formula	C₁₅H₂₀O₄
Molecular Weight	264.31700
Flash Point	276.1ºC
Exact Mass	264.13600
PSA	77.76000
LogP	0.71630
Vapour Pressure	1.61E-12mmHg at 25°C
Index of Refraction	1.619

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WH0204300

CHEMICAL NAME :: Sprio(cyclopropane-1,5'-(5H)inden)-7'(6'H)-one, 2',3'-dihydro-3',6'-dihydroxy-2'-(hydroxy methyl)-2',4',6'-trimethyl-, (2'S,3'R,6'R)-

CAS REGISTRY NUMBER :: 1149-99-1

BEILSTEIN REFERENCE NO. :: 2336420

LAST UPDATED :: 199612

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C15-H20-O4

MOLECULAR WEIGHT :: 264.35

WISWESSER LINE NOTATION :: L56 FV HXTJ BQ C1Q C1 GQ G1 I1 H-& AL3XTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 30 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 15 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 15600 ng/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 215,179,1989

127-09-3 structure

127-09-3

~%

1146-04-9 structure

1146-04-9

28282-65-7 structure

28282-65-7

1149-99-1 structure

1149-99-1

Literature: McMorris, Trevor C.; Yu, Jian; Herman, David M.; Kelner, Michael J.; Dawe, Robin; Minamida, Akira Journal of Labelled Compounds and Radiopharmaceuticals, 1998 , vol. 41, # 4 p. 279 - 285

Precursor 1
127-09-3
DownStream 2
25532-76-7 158440-71-2

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