1020719-62-3

1020719-62-3 structure

Name: Pirfenidone D5
Chemical Name: 5-methyl-1-(2,3,4,5,6-pentadeuteriophenyl)pyridin-2-one
CAS Number: 1020719-62-3
Molecular Formula: C₁₂H₆D₅NO
Molecular Weight: 190.25300
Catalog: Signaling Pathways GPCR/G Protein CCR
Create Date: 2017-06-18 20:01:26
Modify Date: 2026-07-10 11:25:10
Pirfenidone D5 (AMR69 D5) is a deuterium labeled Pirfenidone. Pirfenidone is an antifibrotic agent that attenuates CCL2 and CCL12 production in fibrocyte cells. Pirfenidone has growth-inhibitory effect and reduces TGF-β2 protein levels in human glioma cell lines. Pirfenidone also has anti-inflammatory activities[1][2][3].

Name	5-methyl-1-(2,3,4,5,6-pentadeuteriophenyl)pyridin-2-one
Synonyms	Pirfenidone-d5Q: What is Pirfenidone-d5 Q: What is the CAS Number of Pirfenidone-d5 Q: What is the storage condition of Pirfenidone-d5 Q: What e the applications of Pirfenidone-d5 2(1H)-Pyridinone, 5-methyl-1-(phenyl-2,3,4,5,6-d5) Pirfenidone-d5 5-Methyl-1-(phenyl-2,3,4,5,6-d5)-2(1H)-pyridinone AMR69 D5 D5-Pirfenidone 2(1H)-Pyridinone, 5-Methyl-1-phenyl-d5 5-Methyl-N-phenyl-H-pyridone-d5 ( Pirfenidone-d5 ) 5-Methyl-N-phenyl-2-1H-pyridone-d5 5-methyl-1-[(2,3,4,5,H)phenyl]-1,2-dihydropyridin-2-one [2H5]-Pirfenidone Pirfenidone-d5 (5-Methyl-N-Phenyl-H-Pyridone-d5)

Description	Pirfenidone D5 (AMR69 D5) is a deuterium labeled Pirfenidone. Pirfenidone is an antifibrotic agent that attenuates CCL2 and CCL12 production in fibrocyte cells. Pirfenidone has growth-inhibitory effect and reduces TGF-β2 protein levels in human glioma cell lines. Pirfenidone also has anti-inflammatory activities[1][2][3].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> CCR Research Areas >> Cancer Signaling Pathways >> Stem Cell/Wnt >> TGF-beta/Smad Signaling Pathways >> TGF-beta/Smad >> TGF-beta/Smad Signaling Pathways >> Immunology/Inflammation >> CCR Research Areas >> Inflammation/Immunology
Target	TGF-β2[1][2] CCL2 and CCL12[3]
References	[1]. Burghardt I, et al. Pirfenidone inhibits TGF-beta expression in malignant glioma cells. Biochem Biophys Res Commun. 2007 Mar 9;354(2):542-7. [2]. Nakazato H, et al. A novel anti-fibrotic agent pirfenidone suppresses tumor necrosis factor-alpha at the translational level. Eur J Pharmacol. 2002 Jun 20;446(1-3):177-85. [3]. Inomata M, et al. Pirfenidone inhibits fibrocyte accumulation in the lungs in bleomycin-induced murine pulmonary fibrosis. Respir Res. 2014 Feb 8;15:16.