Pirfenidone D5

Modify Date: 2024-01-12 17:51:29

Pirfenidone D5 Structure
Pirfenidone D5 structure
Common Name Pirfenidone D5
CAS Number 1020719-62-3 Molecular Weight 190.25300
Density N/A Boiling Point N/A
Molecular Formula C12H6D5NO Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Pirfenidone D5


Pirfenidone D5 (AMR69 D5) is a deuterium labeled Pirfenidone. Pirfenidone is an antifibrotic agent that attenuates CCL2 and CCL12 production in fibrocyte cells. Pirfenidone has growth-inhibitory effect and reduces TGF-β2 protein levels in human glioma cell lines. Pirfenidone also has anti-inflammatory activities[1][2][3].

 Names

Name 5-methyl-1-(2,3,4,5,6-pentadeuteriophenyl)pyridin-2-one
Synonym More Synonyms

 Pirfenidone D5 Biological Activity

Description Pirfenidone D5 (AMR69 D5) is a deuterium labeled Pirfenidone. Pirfenidone is an antifibrotic agent that attenuates CCL2 and CCL12 production in fibrocyte cells. Pirfenidone has growth-inhibitory effect and reduces TGF-β2 protein levels in human glioma cell lines. Pirfenidone also has anti-inflammatory activities[1][2][3].
Related Catalog
Target

TGF-β2[1][2] CCL2 and CCL12[3]

References

[1]. Burghardt I, et al. Pirfenidone inhibits TGF-beta expression in malignant glioma cells. Biochem Biophys Res Commun. 2007 Mar 9;354(2):542-7.

[2]. Nakazato H, et al. A novel anti-fibrotic agent pirfenidone suppresses tumor necrosis factor-alpha at the translational level. Eur J Pharmacol. 2002 Jun 20;446(1-3):177-85.

[3]. Inomata M, et al. Pirfenidone inhibits fibrocyte accumulation in the lungs in bleomycin-induced murine pulmonary fibrosis. Respir Res. 2014 Feb 8;15:16.

 Chemical & Physical Properties

Molecular Formula C12H6D5NO
Molecular Weight 190.25300
Exact Mass 190.11500
PSA 22.00000
LogP 2.14590

 Synonyms

Pirfenidone-d5
5-Methyl-N-phenyl-2-1H-pyridone-d5