23800-56-8

23800-56-8 structure

Name: Pogostone
Chemical Name: 4-Hydroxy-6-methyl-3-(4-methylpentanoyl)-2H-pyran-2-one
CAS Number: 23800-56-8
Molecular Formula: C₁₂H₁₆O₄
Molecular Weight: 224.25300
Catalog: Natural product Phenols
Create Date: 2018-10-17 18:03:56
Modify Date: 2024-01-02 18:46:11
Pogostone is isolated from patchouli with anti-bacterial and anti-cancer activities. Pogostone inhibits both gram negative and gram positive bacteria, also show inhibitory effect on corynebacterium xerosis with a MIC value of 0.098 µg/ml [2]. Pogostone induces cell apoptosis and autophagy[2].

Name	4-Hydroxy-6-methyl-3-(4-methylpentanoyl)-2H-pyran-2-one
Synonyms	Dhelwangin Pogostone

Description	Pogostone is isolated from patchouli with anti-bacterial and anti-cancer activities. Pogostone inhibits both gram negative and gram positive bacteria, also show inhibitory effect on corynebacterium xerosis with a MIC value of 0.098 µg/ml [2]. Pogostone induces cell apoptosis and autophagy[2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Infection Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Inflammation/Immunology Signaling Pathways >> Anti-infection >> Bacterial
Target	IC50: apoptosis; autophagy; bacteria[1][2]
In Vitro	Pogostone shows inhibitory effects on HCT116 cell with an IC50 value of 18.7±1.93 µg/ml, and show strikingly lower cytotoxicity on normal human embryonic kidney cell 293A (IC50: 95.13±19.44 µg/ml) and endothelial cell HUVEC (IC50: 112±20.77 µg/ml)[1].
In Vivo	Pogostone ( intraperitoneal injection; 25, 50 and 100 mg/kg) shows antibacterial activity in vivo against Escherichia coli (E. coli) and MRSA. Ninety percent of the mice infected with E. coil could be protected at the concentrations of 50 and 100 mg/kg, and 60% of the mice at 25 mg/kg, while the rate of protection for the mice infected with MRSA was 60% and 50% at doses of 100 and 50 mg/kg, respectively[2].
References	[1]. Peng F, et al. In vitro and in vivo antibacterial activity of Pogostone.Chin Med J (Engl). 2014;127(23):4001-5. [2]. Cao ZX, et al. Pogostone induces autophagy and apoptosis involving PI3K/Akt/mTOR axis in human colorectal carcinoma HCT116 cells.J Ethnopharmacol. 2017 Apr 18;202:20-27.

Density	1.185±0.06 g/cm3 (20 ºC 760 Torr)
Boiling Point	348.2±42.0 ºC (760 Torr)
Molecular Formula	C₁₂H₁₆O₄
Molecular Weight	224.25300
Flash Point	129.9±21.4 ºC
Exact Mass	224.10500
PSA	67.51000
LogP	2.27270
Storage condition	2-8C

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