99957-90-1

99957-90-1 structure

99957-90-1 structure

Name: Org30958
Chemical Name: (8S,9S,10S,13S,14S)-10-[(ethyldisulfanyl)methyl]-13-methyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,17-dione
CAS Number: 99957-90-1
Molecular Formula: C₂₁H₃₀O₂S₂
Molecular Weight: 378.59200
Catalog: Research Areas Metabolic Disease
Create Date: 2017-08-11 22:28:25
Modify Date: 2024-01-17 17:49:38
Org30958 is a potent aromatase inhibitor in vivo.

Name	(8S,9S,10S,13S,14S)-10-[(ethyldisulfanyl)methyl]-13-methyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,17-dione
Synonyms	Org30958

Description	Org30958 is a potent aromatase inhibitor in vivo.
Related Catalog	Research Areas >> Metabolic Disease Signaling Pathways >> Others >> Aromatase
Target	Aromatase[1]
In Vivo	Besides inhibition of cornification of vaginal epithelium Org30958 (ORG 30958) decreases ovarian aromatase and plasma E2 levels in DHEAS-treated hypophysectomized rats. Plasma estradiol levels are also lowered by Org30958 in dogs which are treated with pregnant mare serum gonadotrophin in order to induce pro-estrus. Org30958 displays much less than 1/400th of the androgenic activity of testosterone propionate in immature castrated rats and appears to be devoid of estrogenic and anti-estrogenic activity in ovariectomized mature rats. A twice daily dose of 1.5 mg Org30958/kg postpones ovulation in mature female rats[1].
References	[1]. Geelen JA, et al. Selection of 19-(ethyldithio)-androst-4-ene-3,17-dione (ORG 30958): a potent aromatase inhibitor in vivo. J Steroid Biochem Mol Biol. 1991 Feb;38(2):181-8.

Density	1.19g/cm3
Boiling Point	532.1ºC at 760 mmHg
Molecular Formula	C₂₁H₃₀O₂S₂
Molecular Weight	378.59200
Flash Point	220.9ºC
Exact Mass	378.16900
PSA	84.74000
LogP	5.46880
Index of Refraction	1.592

Hazard Codes	Xi