101714-41-4
101714-41-4 structure
- Name: BiP inducer X
- Chemical Name: [2-(3,4-dihydroxyphenyl)-2-oxoethyl] thiocyanate
- CAS Number: 101714-41-4
- Molecular Formula: C9H7NO3S
- Molecular Weight: 209.22
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2018-12-18 18:32:03
- Modify Date: 2025-08-25 11:25:22
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BiP inducer X, a selective inducer of immunoglobulin heavy chain binding protein (BiP)/GRP78, is an effective ER (endoplasmic reticulum) stress inhibitor. BiP inducer X preferentially induces BiP with slight inductions of GRP94, calreticulin, and C/EBP homologous protein. BiP inducer X protects neurons from ER stress[1][2].
| Name | [2-(3,4-dihydroxyphenyl)-2-oxoethyl] thiocyanate |
|---|---|
| Synonyms |
BIX
1-(3,4-dihydroxyphenyl)-2-thiocyanate-ethanone 2-(3,4-Dihydroxyphenyl)-2-oxoethyl thiocyanate 1-(3,4-Dihydroxy-phenyl)-2-thiocyanato-aethanon Thiocyanicacid,3,4-dihydroxyphenacyl ester (6CI) 1-(3,4-dihydroxy-phenyl)-2-thiocyanato-ethanone BiP inducer X Thiocyanic acid, 2-(3,4-dihydroxyphenyl)-2-oxoethyl ester Thiocyanic acid,2-(3,4-dihydroxyphenyl)-2-oxoethyl ester Thiocyanic acid, 2-(3,4-dihydroxyphenyl)-2-oxoethyl ester (9CI) |
| Description | BiP inducer X, a selective inducer of immunoglobulin heavy chain binding protein (BiP)/GRP78, is an effective ER (endoplasmic reticulum) stress inhibitor. BiP inducer X preferentially induces BiP with slight inductions of GRP94, calreticulin, and C/EBP homologous protein. BiP inducer X protects neurons from ER stress[1][2]. |
|---|---|
| Related Catalog | |
| In Vitro | BiP inducer X (5 μM; 0-12 hours; SK-N-SH cells) increase BiP protein[1]. The induction of BiP by BiP inducer X (BIX) is mediated by activation of ER stress response elements (ERSEs) through the ATF6 pathway[1]. BiP inducer X (5 μM; 12 hours; pretreatment with SK-N-SH cells) inhibits cell death induced by ER stress involving inhibited activation of caspases 3/7 and 4[1]. |
| In Vivo | BiP inducer X administration reduces the insults due to cerebral infarction[1]. A 20 μg portion of BiP inducer X administration reduces ER stress-induced apoptosis induced in the penumbra by MCA occlusion[1]. Animal Model: Male adult ddY mice weighing 24-34 g (Japan SLC)[1] Dosage: 20 μg (2 μl) Administration: Intracerebroventricularly Result: Significantly increased the level of BiP protein 24 h after administration, confirming that administration of BIX induces BiP protein in vivo. |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 517.1±45.0 °C at 760 mmHg |
| Melting Point | 127 °C |
| Molecular Formula | C9H7NO3S |
| Molecular Weight | 209.22 |
| Flash Point | 266.5±28.7 °C |
| Exact Mass | 209.014664 |
| PSA | 106.62000 |
| LogP | 1.53 |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
| Index of Refraction | 1.665 |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H317 |
| Precautionary Statements | P280 |
| Hazard Codes | Xn |
| RIDADR | NONH for all modes of transport |
|
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101714-41-4 |
| Literature: Bariana et al. Journal of the Indian Chemical Society, 1955 , vol. 32, p. 427,428, 429 |
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101714-41-4 |
| Literature: Dzierzgowski Chemische Berichte, 1894 , vol. 27, p. 1982 |
