101714-41-4

101714-41-4 structure

Name: BiP inducer X
Chemical Name: [2-(3,4-dihydroxyphenyl)-2-oxoethyl] thiocyanate
CAS Number: 101714-41-4
Molecular Formula: C₉H₇NO₃S
Molecular Weight: 209.22
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2018-12-18 18:32:03
Modify Date: 2024-01-04 14:41:20
BiP inducer X, a selective inducer of immunoglobulin heavy chain binding protein (BiP)/GRP78, is an effective ER (endoplasmic reticulum) stress inhibitor. BiP inducer X preferentially induces BiP with slight inductions of GRP94, calreticulin, and C/EBP homologous protein. BiP inducer X protects neurons from ER stress[1][2].

Name	[2-(3,4-dihydroxyphenyl)-2-oxoethyl] thiocyanate
Synonyms	BIX 1-(3,4-dihydroxyphenyl)-2-thiocyanate-ethanone 2-(3,4-Dihydroxyphenyl)-2-oxoethyl thiocyanate 1-(3,4-Dihydroxy-phenyl)-2-thiocyanato-aethanon Thiocyanicacid,3,4-dihydroxyphenacyl ester (6CI) 1-(3,4-dihydroxy-phenyl)-2-thiocyanato-ethanone BiP inducer X Thiocyanic acid, 2-(3,4-dihydroxyphenyl)-2-oxoethyl ester Thiocyanic acid,2-(3,4-dihydroxyphenyl)-2-oxoethyl ester Thiocyanic acid, 2-(3,4-dihydroxyphenyl)-2-oxoethyl ester (9CI)

Description	BiP inducer X, a selective inducer of immunoglobulin heavy chain binding protein (BiP)/GRP78, is an effective ER (endoplasmic reticulum) stress inhibitor. BiP inducer X preferentially induces BiP with slight inductions of GRP94, calreticulin, and C/EBP homologous protein. BiP inducer X protects neurons from ER stress[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Neurological Disease
In Vitro	BiP inducer X (5 μM; 0-12 hours; SK-N-SH cells) increase BiP protein[1]. The induction of BiP by BiP inducer X (BIX) is mediated by activation of ER stress response elements (ERSEs) through the ATF6 pathway[1]. BiP inducer X (5 μM; 12 hours; pretreatment with SK-N-SH cells) inhibits cell death induced by ER stress involving inhibited activation of caspases 3/7 and 4[1].
In Vivo	BiP inducer X administration reduces the insults due to cerebral infarction[1]. A 20 μg portion of BiP inducer X administration reduces ER stress-induced apoptosis induced in the penumbra by MCA occlusion[1]. Animal Model: Male adult ddY mice weighing 24-34 g (Japan SLC)[1] Dosage: 20 μg (2 μl) Administration: Intracerebroventricularly Result: Significantly increased the level of BiP protein 24 h after administration, confirming that administration of BIX induces BiP protein in vivo.
References	[1]. Kudo T, et al. A molecular chaperone inducer protects neurons from ER stress. Cell Death Differ. 2008;15(2):364-375. [2]. Yoo SA, et al. A novel pathogenic role of the ER chaperone GRP78/BiP in rheumatoid arthritis. J Exp Med. 2012;209(4):871-886.

Density	1.5±0.1 g/cm3
Boiling Point	517.1±45.0 °C at 760 mmHg
Melting Point	127 °C
Molecular Formula	C₉H₇NO₃S
Molecular Weight	209.22
Flash Point	266.5±28.7 °C
Exact Mass	209.014664
PSA	106.62000
LogP	1.53
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.665

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H317
Precautionary Statements	P280
Hazard Codes	Xn
RIDADR	NONH for all modes of transport

99-40-1

333-20-0

101714-41-4

Literature: Bariana et al. Journal of the Indian Chemical Society, 1955 , vol. 32, p. 427,428, 429

99-40-1

1147550-11-5

101714-41-4

Literature: Dzierzgowski Chemische Berichte, 1894 , vol. 27, p. 1982

Precursor 2
99-40-1 333-20-0
DownStream 0

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