31298-54-1

31298-54-1 structure

Name: Panepoxydone
Chemical Name: (1S,2R,6S)-2-hydroxy-4-(1-hydroxy-3-methylbut-2-enyl)-7-oxabicyclo[4.1.0]hept-3-en-5-one
CAS Number: 31298-54-1
Molecular Formula: C₁₁H₁₄O₄
Molecular Weight: 210.22600
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2017-11-28 06:40:26
Modify Date: 2024-01-10 19:32:23
Panepoxydone is an inhibitor of NF-κB activation. Panepoxydone interferes with the NF-κB mediated signal transduction by inhibiting the phosphorylation of IκB. Panepoxydone exhibits antitumor, anti-inflammatory, antimalarial and anti-parasitic activity[1][2].

Name	(1S,2R,6S)-2-hydroxy-4-(1-hydroxy-3-methylbut-2-enyl)-7-oxabicyclo[4.1.0]hept-3-en-5-one
Synonyms	SL-3042 (1s,5r,6s)-5-hydroxy-3-(1-hydroxy-3-methylbut-2-en-1-yl)-7-oxabicyclo[4.1.0]hept-3-en-2-one Antibiotic SL-3042 Panepoxydone

Description	Panepoxydone is an inhibitor of NF-κB activation. Panepoxydone interferes with the NF-κB mediated signal transduction by inhibiting the phosphorylation of IκB. Panepoxydone exhibits antitumor, anti-inflammatory, antimalarial and anti-parasitic activity[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Research Areas >> Infection Research Areas >> Inflammation/Immunology
References	[1]. Arora R, et, al. Panepoxydone targets NF-kB and FOXM1 to inhibit proliferation, induce apoptosis and reverse epithelial to mesenchymal transition in breast cancer. PLoS One. 2014 Jun 4;9(6):e98370. [2]. Erkel G, et, al. Influence of the fungal NF-kappaB inhibitor panepoxydone on inflammatory gene expression in MonoMac6 cells. Int Immunopharmacol. 2007 May;7(5):612-24.