Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 6-Amino-1-[4-(3-methyl-1-oxobutyl)-1-piperazinyl]-1-hexanone hydrochloride
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Purity: 98.0%
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789488-77-3

789488-77-3 structure

Name: ENMD-1068
Chemical Name: 6-amino-1-[4-(3-methylbutanoyl)piperazin-1-yl]hexan-1-one
CAS Number: 789488-77-3
Molecular Formula: C₁₅H₂₉N₃O₂
Molecular Weight: 283.41000
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2017-07-12 15:39:40
Modify Date: 2024-09-11 17:44:05
ENMD-1068 is a selective protease-activated receptor 2 (PAR2) antagonist. ENMD-1068 reduces hepatic stellate cell activation and collagen expression by inhibiting TGF-β1/Smad signaling. ENMD-1068 also inhibits the proliferation of endometrial cells and induces apoptosis of epithelial cells in the lesion. ENMD-1068 can be used in the study of endometriosis and liver fibrosis[1][2].

Name	6-amino-1-[4-(3-methylbutanoyl)piperazin-1-yl]hexan-1-one
Synonyms	enmd-1068 unii-stv44cbk1w

Description	ENMD-1068 is a selective protease-activated receptor 2 (PAR2) antagonist. ENMD-1068 reduces hepatic stellate cell activation and collagen expression by inhibiting TGF-β1/Smad signaling. ENMD-1068 also inhibits the proliferation of endometrial cells and induces apoptosis of epithelial cells in the lesion. ENMD-1068 can be used in the study of endometriosis and liver fibrosis[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Signaling Pathways >> GPCR/G Protein >> Protease-Activated Receptor (PAR) Research Areas >> Inflammation/Immunology
References	[1]. Sun Q, et al. ENMD-1068 inhibits liver fibrosis through attenuation of TGF-β1/Smad2/3 signaling in mice. Sci Rep. 2017 Jul 14;7(1):5498. doi: 10.1038/s41598-017-05190-7. Erratum in: Sci Rep. 2019 Dec 10;9(1):19125. [2]. Wang Y, et al. ENMD-1068, a protease-activated receptor 2 antagonist, inhibits the development of endometriosis in a mouse model. Am J Obstet Gynecol. 2014 Jun;210(6):531.e1-8.

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