1258597-47-5

1258597-47-5 structure

Name: Apremilast-d5
Chemical Name: (S)-N-(2-(2-(methylsulfonyl)-1-(3-(ethoxy-d5)-4-(methoxy)phenyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide
CAS Number: 1258597-47-5
Molecular Formula: C₂₂H₁₉D₅N₂O₇S
Molecular Weight: 465.53100
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2017-07-25 22:17:22
Modify Date: 2024-01-02 04:02:20
Apremilast D5 (CC-10004 D5) is a deuterium labeled Apremilast. Apremilast is an orally available inhibitor of type-4 cyclic nucleotide phosphodiesterase (PDE-4) with an IC50 of 74 nM. Apremilast inhibits TNF-α release by lipopolysaccharide (LPS) with an IC50 of 104 nM[1].

Name	(S)-N-(2-(2-(methylsulfonyl)-1-(3-(ethoxy-d5)-4-(methoxy)phenyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide
Synonyms	Apremilast D5 Apremilast-d5

Description	Apremilast D5 (CC-10004 D5) is a deuterium labeled Apremilast. Apremilast is an orally available inhibitor of type-4 cyclic nucleotide phosphodiesterase (PDE-4) with an IC50 of 74 nM. Apremilast inhibits TNF-α release by lipopolysaccharide (LPS) with an IC50 of 104 nM[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE) Research Areas >> Inflammation/Immunology
Target	PDE4 TNF-α
References	[1]. Perez-Aso M, et al. Apremilast, a novel phosphodiesterase 4 (PDE4) inhibitor, regulates inflammation through multiple cAMP downstream effectors. Arthritis Res Ther. 2015 Sep 15;17:249.