38226-86-7

38226-86-7 structure

Name: Anhydroicaritin
Chemical Name: 3,5-dihydroxy-4'-methoxy-6'',6''-dimethyl-4'',5''-dihydropyrano[2'',3'':7,8]-flavone
CAS Number: 38226-86-7
Molecular Formula: C₂₁H₂₀O₆
Molecular Weight: 368.380
Catalog: Biochemical Plant extracts
Create Date: 2018-06-12 15:51:15
Modify Date: 2024-01-02 21:53:47
β-Anhydroicaritin is isolated from Boswellia carterii Birdware, has important biological and pharmacological effects, such as antiosteoporosis, estrogen regulation and antitumor properties[1][2]. β-Anhydroicaritin decreases the overproduction of NO, IL-10, TNF-α, MCP-1 and IL-6 in inperitonitis mice. β-Anhydroicaritin inhibits the elevation of intracellular Ca2+, and markedly decreases iNOS protein expression[3].

Name	3,5-dihydroxy-4'-methoxy-6'',6''-dimethyl-4'',5''-dihydropyrano[2'',3'':7,8]-flavone
Synonyms	3,5-Dihydroxy-2-(4-methoxyphenyl)-8,8-dimethyl-9,10-dihydro-4H,8H-pyrano[2,3-f]chromen-4-one Anhydroicaritin Cycloicaritin 4H,8H-Benzo[1,2-b:3,4-b']dipyran-4-one, 9,10-dihydro-3,5-dihydroxy-2-(4-methoxyphenyl)-8,8-dimethyl- Anhydroicaritin, Beta- Anhydroicaritin, β-

Description	β-Anhydroicaritin is isolated from Boswellia carterii Birdware, has important biological and pharmacological effects, such as antiosteoporosis, estrogen regulation and antitumor properties[1][2]. β-Anhydroicaritin decreases the overproduction of NO, IL-10, TNF-α, MCP-1 and IL-6 in inperitonitis mice. β-Anhydroicaritin inhibits the elevation of intracellular Ca2+, and markedly decreases iNOS protein expression[3].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Interleukin Related Research Areas >> Inflammation/Immunology
References	[1]. Nguyen VS, et al. Synthesis of Icaritin and β-anhydroicaritin Mannich Base Derivatives and Their Cytotoxic Activities on Three Human Cancer Cell Lines. Anticancer Agents Med Chem. 2017;17(1):137-142 [2]. Wu Y, et al. Effect of β-anhydroicaritin on the expression levels of tumor necrosis factor-α and matrix metalloproteinase-3 in periodontal tissue of diabetic rats. Mol Med Rep. 2015 Aug;12(2):1829-37. [3]. Lai X, et al. Protective effect of anhydroicaritin against peritonitis in mice. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2013 Oct;29(10):1036-9.

Density	1.4±0.1 g/cm3
Boiling Point	575.3±50.0 °C at 760 mmHg
Melting Point	222-223 °C
Molecular Formula	C₂₁H₂₀O₆
Molecular Weight	368.380
Flash Point	205.5±23.6 °C
Exact Mass	368.125977
PSA	89.13000
LogP	5.04
Vapour Pressure	0.0±1.7 mmHg at 25°C
Index of Refraction	1.633

Hazard Codes	Xi

489-32-7

~22%

38226-86-7

Literature: Dell'Agli, Mario; Galli, Germana V.; Dal Cero, Esther; Belluti, Federica; Matera, Riccardo; Zironi, Elisa; Pagliuca, Giampiero; Bosisio, Enrica Journal of Natural Products, 2008 , vol. 71, # 9 p. 1513 - 1517

128988-53-4

38226-86-7

Literature: Mizuno, Mizuo; Iinuma, Munekazu; Tanaka, Toshiyuki; Sakakibara, Norio; Murata, Jin; et al. Phytochemistry (Elsevier), 1990 , vol. 29, # 4 p. 1277 - 1281

Precursor 2
489-32-7 128988-53-4
DownStream 0

38226-86-7	118525-40-9
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134104-43-1	131615-57-1
2227752-52-3	6906-52-1
930439-75-1	1018584-77-4