Anhydroicaritin

Modify Date: 2024-01-02 21:53:47

Anhydroicaritin Structure
Anhydroicaritin structure
 Common Name Anhydroicaritin
CAS Number 38226-86-7 Molecular Weight 368.380
Density 1.4±0.1 g/cm3 Boiling Point 575.3±50.0 °C at 760 mmHg
Molecular Formula C21H20O6 Melting Point 222-223 °C
MSDS N/A Flash Point 205.5±23.6 °C

 Use of Anhydroicaritin


β-Anhydroicaritin is isolated from Boswellia carterii Birdware, has important biological and pharmacological effects, such as antiosteoporosis, estrogen regulation and antitumor properties[1][2]. β-Anhydroicaritin decreases the overproduction of NO, IL-10, TNF-α, MCP-1 and IL-6 in inperitonitis mice. β-Anhydroicaritin inhibits the elevation of intracellular Ca2+, and markedly decreases iNOS protein expression[3].

 Names

Name 3,5-dihydroxy-4'-methoxy-6'',6''-dimethyl-4'',5''-dihydropyrano[2'',3'':7,8]-flavone
Synonym More Synonyms

 Anhydroicaritin Biological Activity

Description β-Anhydroicaritin is isolated from Boswellia carterii Birdware, has important biological and pharmacological effects, such as antiosteoporosis, estrogen regulation and antitumor properties[1][2]. β-Anhydroicaritin decreases the overproduction of NO, IL-10, TNF-α, MCP-1 and IL-6 in inperitonitis mice. β-Anhydroicaritin inhibits the elevation of intracellular Ca2+, and markedly decreases iNOS protein expression[3].
Related Catalog
References

[1]. Nguyen VS, et al. Synthesis of Icaritin and β-anhydroicaritin Mannich Base Derivatives and Their Cytotoxic Activities on Three Human Cancer Cell Lines. Anticancer Agents Med Chem. 2017;17(1):137-142

[2]. Wu Y, et al. Effect of β-anhydroicaritin on the expression levels of tumor necrosis factor-α and matrix metalloproteinase-3 in periodontal tissue of diabetic rats. Mol Med Rep. 2015 Aug;12(2):1829-37.

[3]. Lai X, et al. Protective effect of anhydroicaritin against peritonitis in mice. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2013 Oct;29(10):1036-9.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 575.3±50.0 °C at 760 mmHg
Melting Point 222-223 °C
Molecular Formula C21H20O6
Molecular Weight 368.380
Flash Point 205.5±23.6 °C
Exact Mass 368.125977
PSA 89.13000
LogP 5.04
Vapour Pressure 0.0±1.7 mmHg at 25°C
Index of Refraction 1.633

 Safety Information

Hazard Codes Xi

 Synthetic Route

Icariin structure

Icariin

CAS#:489-32-7

~22%

Anhydroicaritin Structure

Anhydroicaritin

CAS#:38226-86-7

Literature: Dell'Agli, Mario; Galli, Germana V.; Dal Cero, Esther; Belluti, Federica; Matera, Riccardo; Zironi, Elisa; Pagliuca, Giampiero; Bosisio, Enrica Journal of Natural Products, 2008 , vol. 71, # 9 p. 1513 - 1517
3-[(2S,3R,4R,5S,6S)-3,5-dihydroxy-6-methyl-4-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-enyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-o structure

3-[(2S,3R,4R,5S...

CAS#:128988-53-4

~%

Anhydroicaritin Structure

Anhydroicaritin

CAS#:38226-86-7

Literature: Mizuno, Mizuo; Iinuma, Munekazu; Tanaka, Toshiyuki; Sakakibara, Norio; Murata, Jin; et al. Phytochemistry (Elsevier), 1990 , vol. 29, # 4 p. 1277 - 1281

 Precursor & DownStream

Precursor  2

DownStream  0

 Synonyms

3,5-Dihydroxy-2-(4-methoxyphenyl)-8,8-dimethyl-9,10-dihydro-4H,8H-pyrano[2,3-f]chromen-4-one
Anhydroicaritin
Cycloicaritin
4H,8H-Benzo[1,2-b:3,4-b']dipyran-4-one, 9,10-dihydro-3,5-dihydroxy-2-(4-methoxyphenyl)-8,8-dimethyl-
Anhydroicaritin, Beta-
Anhydroicaritin, β-
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