5573-16-0

5573-16-0 structure

Name: Saikogenin D
Chemical Name: 3β,16α,23,28-Tetrahydroxyoleana-11(12),13(18)-diene
CAS Number: 5573-16-0
Molecular Formula: C₃₀H₄₈O₄
Molecular Weight: 472.700
Catalog: Signaling Pathways GPCR/G Protein Prostaglandin Receptor
Create Date: 2018-08-11 15:09:53
Modify Date: 2026-07-16 14:44:28
Saikogenin D is isolated from Bupleurum chinense, has anti-inflammatory effects. Saikogenin D activates epoxygenases that converts arachidonic acid to epoxyeicosanoids and dihydroxyeicosatrienoic acids, and the metabolites secondarily inhibit prostaglandin E2 (PGE2) production. Saikogenin D results in an elevation of [Ca2+]i due to Ca2+ release from intracellular stores[1][2].

Name	3β,16α,23,28-Tetrahydroxyoleana-11(12),13(18)-diene
Synonyms	SAIKOGENIN D Oleana-11,13-diene-3,16,23,28-tetrol, (3β,4α,16α) (3β,16α)-Oleana-11,13(18)-diene-3,16,23,28-tetrol (4R)-Oleana-11,13-diene-3β,16α,23,28-tetrol (3S,4R,6,6bS,8R,8aS,14,14bS)-4,8a-Bis(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,14a,14b-octadecahydropicene-3,8-diol

Description	Saikogenin D is isolated from Bupleurum chinense, has anti-inflammatory effects. Saikogenin D activates epoxygenases that converts arachidonic acid to epoxyeicosanoids and dihydroxyeicosatrienoic acids, and the metabolites secondarily inhibit prostaglandin E2 (PGE2) production. Saikogenin D results in an elevation of [Ca2+]i due to Ca2+ release from intracellular stores[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor Research Areas >> Inflammation/Immunology Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
In Vitro	Saikogenin D (1-20 μM) inhibits PGE2 production induced by the Ca2+ ionophore A23187 in a concentration-dependent manner with an IC50 value of 3 μM in C6 rat glioma cells[1]. Saikogenin D (10-100 μM) elevates [Ca2+]i in a concentration-dependent manner with a EC50 value of 35 μM in the presence or absence of extracellular Ca2+ in C6 rat glioma cells[1].
References	[1]. Toriniwa Y, et al. Participation of epoxygenase activation in saikogenin D-induced inhibition of prostaglandin E(2) synthesis.J Pharm Pharmacol. 2006 Jun;58(6):859-66. [2]. Kodama Y, et al. Dual effect of saikogenin D: in vitro inhibition of prostaglandin E2 production and elevation of intracellular free Ca2+ concentration in C6 rat glioma cells.Planta Med. 2003 Aug;69(8):765-7.