1027513-54-7

1027513-54-7 structure

Name: PSB 0788
Chemical Name: 8-(4-(4-(4-chlorobenzyl)piperazine-1-sulfonyl)phenyl)-1-propyl-3,7-dihydropurine-2,6-dione
CAS Number: 1027513-54-7
Molecular Formula: C₂₅H₂₇ClN₆O₄S
Molecular Weight: 543.03800
Catalog: Signaling Pathways GPCR/G Protein Adenosine Receptor
Create Date: 2016-11-15 13:54:04
Modify Date: 2024-01-09 08:31:23
PSB-0788 (compound 17), xanthine-8-yl-benzenesulfonamide derivative, is a new selective high-affinity A2B antagonist with IC50 value of 3.64 nM and Ki value of 0.393 nM, respeactively. PSB-0788 (compound 17) can be used for the research for chronic inflammatory lung diseases[1].

Name	8-(4-(4-(4-chlorobenzyl)piperazine-1-sulfonyl)phenyl)-1-propyl-3,7-dihydropurine-2,6-dione
Synonyms	5-Nonyloxytryptamine oxalate

Description	PSB-0788 (compound 17), xanthine-8-yl-benzenesulfonamide derivative, is a new selective high-affinity A2B antagonist with IC50 value of 3.64 nM and Ki value of 0.393 nM, respeactively. PSB-0788 (compound 17) can be used for the research for chronic inflammatory lung diseases[1].
Related Catalog	Research Areas >> Cancer Research Areas >> Infection Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor
Target	IC50: 3.64 nM (A2BAdoR); Ki: 0.393 nM (human, A2B); >1000 nM ( A3 human recombinant); 333 nM ( A2A human recombinant); 1730 nM ( A2A rat brain striatal membranes); 2240 nM ( A1 human recombinant); 386 nM ( A1 rat brain cortical membranes))[1].[1]
In Vitro	PSB-0788 (compound 17) has high potency at the A2BAdoR with IC50 value of 3.64 nM. PSB-0788 (compound 17) has good profile of affinity and selectivity (Ki: 0.393 nM ( A2B human recombinant); >1000 nM ( A3 human recombinant); 333 nM ( A2A human recombinant); 1730 nM ( A2A rat brain striatal membranes); 2240 nM ( A1 human recombinant); 386 nM ( A1 rat brain cortical membranes))[1].
References	[1]. Thomas Borrmann, et al. 1-alkyl-8-(piperazine-1-sulfonyl)phenylxanthines: development and characterization of adenosine A2B receptor antagonists and a new radioligand with subnanomolar affinity and subtype specificity. J Med Chem. 2009 Jul 9;52(13):3994-4006.