1622921-15-6
1622921-15-6 structure
- Name: Remodelin hydrobromide
- Chemical Name: Benzonitrile, 4-[2-(2-cyclopentylidenehydrazinyl)-4-thiazolyl]-, hydrobromide (1:1)
- CAS Number: 1622921-15-6
- Molecular Formula: C15H15BrN4S
- Molecular Weight: 363.275
- Catalog: Biochemical Inhibitor Epigenetics Histone Acetyltransferase inhibitor
- Create Date: 2017-05-30 18:24:29
- Modify Date: 2024-01-08 10:26:09
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Remodelin HBr salt is a novel potent and selective inhibitor of the acetyl-transferase protein NAT10.IC50 value:Target: NAT10 inhibitorRemodelin can improve nuclear architecture, chromatin organization, and fitness of both human lamin A/C-depleted cells and HGPS-derived patient cells, and decrease markers of DNA damage in these cells. Using a combination of chemical, cellular, and genetic approaches, acetyl-transferase protein NAT10 was identified as the target of Remodelin that mediated nuclear shape rescue in laminopathic cells via microtubule reorganization. Down-regulation and mutations of the nuclear-architecture proteins lamin A and C cause misshapen nuclei and altered chromatin organization associated with cancer and laminopathies, including the premature-aging disease Hutchinson-Gilford progeria syndrome (HGPS). Remodelin is a useful chemical tool to study how NAT10 affects nuclear architecture and suggest alternative strategies for treating laminopathies and aging.
| Name | Benzonitrile, 4-[2-(2-cyclopentylidenehydrazinyl)-4-thiazolyl]-, hydrobromide (1:1) |
|---|---|
| Synonyms |
Benzonitrile, 4-[2-(2-cyclopentylidenehydrazinyl)-4-thiazolyl]-, hydrobromide (1:1)
4-[2-(2-Cyclopentylidenehydrazino)-1,3-thiazol-4-yl]benzonitrile hydrobromide (1:1) Remodelin Remodelin (hydrobromide) |
| Description | Remodelin HBr salt is a novel potent and selective inhibitor of the acetyl-transferase protein NAT10.IC50 value:Target: NAT10 inhibitorRemodelin can improve nuclear architecture, chromatin organization, and fitness of both human lamin A/C-depleted cells and HGPS-derived patient cells, and decrease markers of DNA damage in these cells. Using a combination of chemical, cellular, and genetic approaches, acetyl-transferase protein NAT10 was identified as the target of Remodelin that mediated nuclear shape rescue in laminopathic cells via microtubule reorganization. Down-regulation and mutations of the nuclear-architecture proteins lamin A and C cause misshapen nuclei and altered chromatin organization associated with cancer and laminopathies, including the premature-aging disease Hutchinson-Gilford progeria syndrome (HGPS). Remodelin is a useful chemical tool to study how NAT10 affects nuclear architecture and suggest alternative strategies for treating laminopathies and aging. |
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| Related Catalog | |
| References |
| Molecular Formula | C15H15BrN4S |
|---|---|
| Molecular Weight | 363.275 |
| Exact Mass | 362.020081 |
| PSA | 89.31000 |
| LogP | 5.05478 |
| Storage condition | -20℃ |