Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Cyclen
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Cyclen
Price: ￥228.0/5g ￥708.0/25g ￥1178.0/20mg
Purity: 97.0%
Stocking Period: 3 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Cyclen
Price: $280.0/20mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Cyclen
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Henan Tianfu Chemical Co., Ltd.
China
Product Name: 1,4,7,10-tetraazacyclododecane
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

294-90-6

294-90-6 structure

294-90-6 structure

Name: Cyclen
Chemical Name: 1,4,7,10-tetraazacyclododecane
CAS Number: 294-90-6
Molecular Formula: C₈H₂₀N₄
Molecular Weight: 172.27
Catalog: Organic raw materials Amino compound Sulfonic acid amino compound
Create Date: 2018-09-24 18:43:25
Modify Date: 2024-01-02 05:52:40
Cyclen is the aza analogue of crown ether, used as a precursor for MRI contrast agents, and is an intermediate for the preparation of effective macrocyclic chelates[1].

Name	1,4,7,10-tetraazacyclododecane
Synonyms	Tetraaza-12-crown-4 T-12-M DM GM JMTJ Cyclen 1,4,7,10-tetrazacyclododecane MFCD00066281 1,4,7,10-Tetraazacyclododecane 5-26-11-00023 (Beilstein Handbook Reference) [12]aneN4 1,4,7,12-tetraazacyclodedecane EINECS 202-928-3

Description	Cyclen is the aza analogue of crown ether, used as a precursor for MRI contrast agents, and is an intermediate for the preparation of effective macrocyclic chelates[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
References	[1]. Rashid HU, et al. Cyclen-based Gd3+ complexes as MRI contrast agents: Relaxivity enhancement and ligand design. Bioorg Med Chem. 2016 Nov 15;24(22):5663-5684.

Density	0.9±0.1 g/cm3
Boiling Point	283.8±8.0 °C at 760 mmHg
Melting Point	110-113 °C(lit.)
Molecular Formula	C₈H₂₀N₄
Molecular Weight	172.27
Flash Point	129.5±13.5 °C
Exact Mass	172.168793
PSA	48.12000
LogP	-2.34
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.424
Storage condition	Refrigerator

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XA5253000

CHEMICAL NAME :: 1,4,7,10-Tetraazacyclododecane

CAS REGISTRY NUMBER :: 294-90-6

BEILSTEIN REFERENCE NO. :: 0606114

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C8-H20-N4

MOLECULAR WEIGHT :: 172.32

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 388 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NATWAY Naturwissenschaften. (Springer-Verlag, Heidelberger Platz 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.1- 1913- Volume(issue)/page/year: 70,201,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 435 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 19,425,1984

Symbol	GHS05, GHS07, GHS09
Signal Word	Danger
Hazard Statements	H302-H312-H314-H410
Precautionary Statements	P273-P280-P305 + P351 + P338-P310-P501
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant;
Risk Phrases	R36/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	XA5253000
Packaging Group	I; II; III
HS Code	2933990090

Precursor 8
74199-09-0 52667-88-6 55442-07-4 112-24-3
368864-09-9 331230-41-2 773837-37-9 10045-25-7
DownStream 10
64317-97-1 14937-39-4 18084-64-5 185130-32-9
289685-84-3 272120-41-9 60239-18-1 1023970-58-2
157599-02-5 122555-91-3

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%