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Dayang Chem (Hangzhou) Co., Ltd.
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Henan Tianfu Chemical Co., Ltd.
China
Product Name: 1,4,7,10-tetraazacyclododecane
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294-90-6

294-90-6 structure

294-90-6 structure

Name: Cyclen
Chemical Name: 1,4,7,10-tetraazacyclododecane
CAS Number: 294-90-6
Molecular Formula: C₈H₂₀N₄
Molecular Weight: 172.27
Catalog: Organic raw materials Amino compound Sulfonic acid amino compound
Create Date: 2018-09-24 18:43:25
Modify Date: 2026-07-01 12:24:55
Cyclen is the aza analogue of crown ether, used as a precursor for MRI contrast agents, and is an intermediate for the preparation of effective macrocyclic chelates[1].

Name	1,4,7,10-tetraazacyclododecane
Synonyms	Gadobutrol Impurity 39 10-[(1SR,2RS)-2,3-dihydroxy-1- hydroxymethylpropyl]-1,4,7,10- tetraazacyclododecane-1,4,7-triacetic acid 1,4,7,10-Tetraazacyclododecane, CYCLEN Kryptofix 11 aza 1,4,7,10-tetrazacyclododecane {Cyclene) Cyclen(M-100) 1,4,7,10-tetrazacyclododecane MFCD00066281 5-26-11-00023 (Beilstein Handbook Reference) Tetraazacyclododecane (Cyclen) 1,4,7,10-TETRAAZACYCLODODECANE 1,4,7,10-Tetraazacyclododecane (6CI, 8CI, 9CI, ACI) CYCLEN 1,4,7,10-Tetraazacyclododecane, min Gadobutrol Impurity 39 (Cyclen) GDP-mannose 4 Cyclen,1,4,7,10-Tetrazacyclododecane POTASSIUM SULFITE 10-1 Cyclen, >= Gadolinium Butanol Impurity 27 Gm-D [12]aneN4 EINECS 202-928-3 1,4,7,10-tetraazacyc 1,4,7,10-TETRAAZACYCLODODECANEHCL CYCLEN wheel ring vine Ning Tetraaza-12-crown-4 T-12-M DM GM JMTJ 1,4,7,10-Tetrazacyclododecane Gadobutrol Impurity 46 Gadobutrol Impurity 68 Tetraaza-12-Crown-4 ( CYclen) 1,4,7,10-TETRAAZACYCLODODECANE(CYCLEN) 1,4,7,10-Tetraazacyclododecane 1,4,7,10-Tetraazacyclododecane,min.CYCLEN 1,4,7,12-tetraazacyclodedecane Ring rattan, ning 1,4,7,10-Tetracyclododecane 1,4,7,1-Tetraazacyclododecane Gadobutrol Impurity 12 4HCl Tetraaza 12-crown-4 Cyclen, 10 mM in DMSO SDR3E1 1,4,7,10-Tetraazacyclododecane( Cyclenine ) Gadolinium Butanol Impurity 39 Cyclen ( 1,4,7,10-Tetraaza Cyclododecane) 10-Tetraazacyclododecane

Description	Cyclen is the aza analogue of crown ether, used as a precursor for MRI contrast agents, and is an intermediate for the preparation of effective macrocyclic chelates[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
References	[1]. Rashid HU, et al. Cyclen-based Gd3+ complexes as MRI contrast agents: Relaxivity enhancement and ligand design. Bioorg Med Chem. 2016 Nov 15;24(22):5663-5684.

Density	0.9±0.1 g/cm3
Boiling Point	283.8±8.0 °C at 760 mmHg
Melting Point	110-113 °C(lit.)
Molecular Formula	C₈H₂₀N₄
Molecular Weight	172.27
Flash Point	129.5±13.5 °C
Exact Mass	172.168793
PSA	48.12000
LogP	-2.34
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.424
Storage condition	Refrigerator

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XA5253000

CHEMICAL NAME :: 1,4,7,10-Tetraazacyclododecane

CAS REGISTRY NUMBER :: 294-90-6

BEILSTEIN REFERENCE NO. :: 0606114

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C8-H20-N4

MOLECULAR WEIGHT :: 172.32

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 388 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NATWAY Naturwissenschaften. (Springer-Verlag, Heidelberger Platz 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.1- 1913- Volume(issue)/page/year: 70,201,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 435 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 19,425,1984

Symbol	GHS05, GHS07, GHS09
Signal Word	Danger
Hazard Statements	H302-H312-H314-H410
Precautionary Statements	P273-P280-P305 + P351 + P338-P310-P501
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant;
Risk Phrases	R36/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	XA5253000
Packaging Group	I; II; III
HS Code	2933990090

Precursor 8
74199-09-0 52667-88-6 55442-07-4 112-24-3
368864-09-9 331230-41-2 773837-37-9 10045-25-7
DownStream 10
64317-97-1 14937-39-4 18084-64-5 185130-32-9
289685-84-3 272120-41-9 60239-18-1 1023970-58-2
157599-02-5 122555-91-3

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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