Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 4-Hydroxy-3-methoxymandelic acid
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Purity: 98.0%
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55-10-7

55-10-7 structure

Name: Vanillyl mandelic acid
Chemical Name: vanillylmandelic acid
CAS Number: 55-10-7
Molecular Formula: C₉H₁₀O₅
Molecular Weight: 198.173
Catalog: Chemical reagent Organic reagent fatty acid
Create Date: 2018-07-01 19:52:12
Modify Date: 2026-07-27 11:26:15
Vanillylmandelic acid is the endproduct of epinephrine and norepinephrine metabolism. Vanillylmandelic acid can be used as an indication of the disorder in neurotransmitter metabolism as well. Vanillylmandelic acid has antioxidant activity towards DPPH radical with an IC50 value of 33 μM[1].

Name	vanillylmandelic acid
Synonyms	alpha,4-dihydroxy-3-methoxy-benzeneaceticaci Vanilmandelic Acid Benzeneacetic acid, .alpha.,4-dihydroxy-3-methoxy 4-Hydroxy-3-methoxymandelic Acid in Methanol 4-Hydroxy-3-methoxy-DL-mandelic acid Vanilinmandelic Acid DL-Vanillylmandelic acid (2S)-2-hydroxy-2-(4-hydroxy-3-methoxyphenyl)acetate QVYQR DQ CO1 UNII:0DQI268449 Vanillomandelic Acid VANILMANDELIC ACID α,4-Dihydroxy-3-methoxybenzeneacetic acid EINECS 200-224-0 Adrenaline Related Compound 2 Vanillinemandelic acid 4-hydroxy-3-methoxy-phenylglycolic acid 2-Hydroxy-2-(4-hydroxy-3-methoxyphenyl)acetic acid 3-methoxy-p-hydroxymandelic acid Vanilmandelic 3-METHOXY-4-HYDROXY MANDELIC ACID VMA, (VANILLOMANDELIC ACID) ALPHA,4-DIHYDROXY-3-METHOXYBENZENEACETIC ACID DL-4-HYDROXY-3-METHOXYMANDELIC ACID 4-Hydroxy 3-methoxymandelic acid HYDROXYMETHOXYMANDELICACID DL-3-METHOXY-4-HYDROXYMANDELIC ACID dl-α,4-dihydroxy-3-methoxyphenylacetic acid Hydroxy(4-hydroxy-3-methoxyphenyl)acetic acid DL -4-Hydroxy-3-methoxymandelic acid 4-Hydroxy-3-MethoxyMandelic acid, R DL-VANILLOMANDELIC ACID DL-4-Hydroxy-3-methoxymandelicAcid> (±)-4-Hydroxy-3-methoxymandelic acid solution 3-METHOXY-4-HYDROXYMANDELIC ACID 4-Hydroxy-3-methoxyphenyl(hydroxy)acetic acid (4-Hydroxy-3-methoxyphenyl)glycolic acid Vanillylmandelic acid, 10 mM in DMSO 4-HYDROXY-3-METHOXYMANDELIC ACID HYDROXY-3-METHOXYMANDELIC ACID, D,L-4 Benzeneacetic acid, α,4-dihydroxy-3-methoxy VANILLOMANDELIC ACID VMA VANILLYLMANDELIC ACID 4-HYDROXY-3-METHOXYMANDELICACID,REAGENT (2S)-2-hydroxy-2-(4-hydroxy-3-methoxy-phenyl)acetic acid 4-Hydroxy-3-methoxymandelic acid α,4-Dihydroxy-3-methoxybenzeneacetic acid, Vanillomandelic acid, Vanillylmandelic acid, Vanilmandelic acid, VMA 3-methoxy-4-hydroxymandelic acid (+/-)-4-HYDROXY-3-METHOXYMANDELIC ACID 4-hydroxy 3-methoxy mandelic acid(VMA) MFCD00004235 Vanillinmandelic acid

Description	Vanillylmandelic acid is the endproduct of epinephrine and norepinephrine metabolism. Vanillylmandelic acid can be used as an indication of the disorder in neurotransmitter metabolism as well. Vanillylmandelic acid has antioxidant activity towards DPPH radical with an IC50 value of 33 μM[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Others >> Others
In Vitro	Vanillylmandelic acid has antioxidant activity, the IC50 value is determined as the amount of VMA required to reduce 50% of the starting concentration of free radical is 33*10-6 M in the UV-Vis decolourisation DPPH assay[1].
In Vivo	Vanillylmandelic acid (intra-arterial injection over 1 min; 1, 10 and 100 mg/kg; the 60 min-observation period) produces a significant difference between vanillylmandelic acid groups and controls. Vanillylmandelic acid decreases the heart rate by 17.5%, 17.9% and 18.9% after 1, 10 and 100 mg/kg, respectively. Mean blood pressure is decreased by 13.5% in control animals as compared to 37%, 23% and 26% after 1, 10 and 100 mg/kg, respectively, in wistar rats[1].
References	[1]. Michalis K Kolentinis, et al.Cardiovascular effects of vanillylmandelic acid in rats. Eur J Pharmacol. 2013 Mar 5;703(1-3):46-52. [2]. Dušan Dimić, et al. Experimental and theoretical elucidation of structural and antioxidant properties of vanillylmandelic acid and its carboxylate anion. Spectrochim Acta A Mol Biomol Spectrosc. 2018 Jun 5;198:61-70.

Density	1.4±0.1 g/cm3
Boiling Point	421.3±45.0 °C at 760 mmHg
Melting Point	132-134 °C (dec.)(lit.)
Molecular Formula	C₉H₁₀O₅
Molecular Weight	198.173
Flash Point	173.7±22.2 °C
Exact Mass	198.052826
PSA	86.99000
LogP	-0.11
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.606
Storage condition	2-8°C

Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	26-36-37/39
RIDADR	UN 1993 3/PG 3
WGK Germany	3
RTECS	CY9033750
Packaging Group	III
Hazard Class	3
HS Code	29036990

2706-75-4

90-05-1

~87%

55-10-7

Literature: Niu, Dong-Fang; Li, Hui-Cheng; Zhang, Xin-Sheng Tetrahedron, 2013 , vol. 69, # 38 p. 8174 - 8177

67-66-3

121-33-5

~66%

55-10-7

Literature: Yang, Ben-Yong; Yang, De-Hong Journal of Chemical Research, 2011 , vol. 35, # 8 p. 484 - 485

52058-11-4

55-10-7

Literature: Gardner; Hibbert Journal of the American Chemical Society, 1944 , vol. 66, p. 607,609

90-05-1

298-12-4

~64%

55-10-7

Literature: Varala, Ravi; Kotra, Vijay; Alam, M. Mujahid; Kumar, N. Ramesh; Ganapaty; Adapa, Srinivas R. Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2008 , vol. 47, # 8 p. 1243 - 1248

Precursor 6
2706-75-4 90-05-1 67-66-3 121-33-5
52058-11-4 298-12-4
DownStream 5
121-33-5 121-34-6 88-14-2 52058-11-4
306-08-1

HS Code	29036990

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