55-10-7

55-10-7 structure

Name: Vanillyl mandelic acid
Chemical Name: vanillylmandelic acid
CAS Number: 55-10-7
Molecular Formula: C₉H₁₀O₅
Molecular Weight: 198.173
Catalog: Chemical reagent Organic reagent fatty acid
Create Date: 2018-07-01 19:52:12
Modify Date: 2024-01-03 10:48:38
Vanillylmandelic acid is the endproduct of epinephrine and norepinephrine metabolism. Vanillylmandelic acid can be used as an indication of the disorder in neurotransmitter metabolism as well. Vanillylmandelic acid has antioxidant activity towards DPPH radical with an IC50 value of 33 μM[1].

Name	vanillylmandelic acid
Synonyms	dl-α,4-dihydroxy-3-methoxyphenylacetic acid Hydroxy(4-hydroxy-3-methoxyphenyl)acetic acid Vanilmandelic Acid 4-Hydroxy-3-methoxy-DL-mandelic acid DL-VANILLOMANDELIC ACID Vanilinmandelic Acid DL-Vanillylmandelic acid 4-Hydroxy-3-methoxyphenyl(hydroxy)acetic acid QVYQR DQ CO1 (4-Hydroxy-3-methoxyphenyl)glycolic acid UNII:0DQI268449 Vanillomandelic Acid α,4-Dihydroxy-3-methoxybenzeneacetic acid EINECS 200-224-0 Vanillinemandelic acid 4-hydroxy-3-methoxy-phenylglycolic acid 3-methoxy-p-hydroxymandelic acid VMA VANILLYLMANDELIC ACID Benzeneacetic acid, α,4-dihydroxy-3-methoxy- 4-Hydroxy-3-methoxymandelic acid 3-methoxy-4-hydroxymandelic acid 4-Hydroxy 3-methoxymandelic acid HYDROXYMETHOXYMANDELICACID MFCD00004235 Vanillinmandelic acid

Description	Vanillylmandelic acid is the endproduct of epinephrine and norepinephrine metabolism. Vanillylmandelic acid can be used as an indication of the disorder in neurotransmitter metabolism as well. Vanillylmandelic acid has antioxidant activity towards DPPH radical with an IC50 value of 33 μM[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Others >> Others
In Vitro	Vanillylmandelic acid has antioxidant activity, the IC50 value is determined as the amount of VMA required to reduce 50% of the starting concentration of free radical is 33*10-6 M in the UV-Vis decolourisation DPPH assay[1].
In Vivo	Vanillylmandelic acid (intra-arterial injection over 1 min; 1, 10 and 100 mg/kg; the 60 min-observation period) produces a significant difference between vanillylmandelic acid groups and controls. Vanillylmandelic acid decreases the heart rate by 17.5%, 17.9% and 18.9% after 1, 10 and 100 mg/kg, respectively. Mean blood pressure is decreased by 13.5% in control animals as compared to 37%, 23% and 26% after 1, 10 and 100 mg/kg, respectively, in wistar rats[1].
References	[1]. Michalis K Kolentinis, et al.Cardiovascular effects of vanillylmandelic acid in rats. Eur J Pharmacol. 2013 Mar 5;703(1-3):46-52. [2]. Dušan Dimić, et al. Experimental and theoretical elucidation of structural and antioxidant properties of vanillylmandelic acid and its carboxylate anion. Spectrochim Acta A Mol Biomol Spectrosc. 2018 Jun 5;198:61-70.

Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	26-36-37/39
RIDADR	UN 1993 3/PG 3
WGK Germany	3
RTECS	CY9033750
Packaging Group	III
Hazard Class	3
HS Code	29036990

2706-75-4

90-05-1

~87%

55-10-7

67-66-3

121-33-5

~66%

55-10-7

Literature: Yang, Ben-Yong; Yang, De-Hong Journal of Chemical Research, 2011 , vol. 35, # 8 p. 484 - 485

52058-11-4

55-10-7

Literature: Gardner; Hibbert Journal of the American Chemical Society, 1944 , vol. 66, p. 607,609

90-05-1

298-12-4

~64%

55-10-7

HS Code	29036990