83209-65-8

83209-65-8 structure

83209-65-8 structure

Name: HC Toxin
Chemical Name: HC toxin
CAS Number: 83209-65-8
Molecular Formula: C₂₁H₃₂N₄O₆
Molecular Weight: 436.50
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2018-03-14 08:00:00
Modify Date: 2024-01-03 18:32:24
HC-Toxin, a cyclic tetrapeptide, is a potent HDAC inhibitor with an IC50 of 30 nM[1]. HC-Toxin induces tumor cell apoptosis and has anticancer effects[2].

Name	HC toxin
Synonyms	3,6-Dimethyl-9-[6-(2-oxiranyl)-6-oxohexyl]decahydropyrrolo[1,2-a][1,4,7,10]tetraazacyclododecine-1,4,7,10-tetrone MFCD00133388 Toxin I HC TOXIN Pyrrolo[1,2-a][1,4,7,10]tetraazacyclododecine-1,4,7,10-tetrone, decahydro-3,6-dimethyl-9-(6-oxiranyl-6-oxohexyl)-

Description	HC-Toxin, a cyclic tetrapeptide, is a potent HDAC inhibitor with an IC50 of 30 nM[1]. HC-Toxin induces tumor cell apoptosis and has anticancer effects[2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC Signaling Pathways >> Epigenetics >> HDAC
In Vitro	HC-Toxin shows potent antiproliferative efficacy and cell cycle arrest at G2/M in T47D human breast cancer cells in a dose-dependent manner. HC-Toxin evokes apoptosis of T47D cells and HC-toxin induced apoptosis might not be mediated through direct increase in caspase-3/7 activity[2].
References	[1]. S J Darkin-Rattray, et al. Apicidin: a novel antiprotozoal agent that inhibits parasite histone deacetylase. Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):13143-7. [2]. Ki Eun Joung, et al. Antiproliferative effect of trichostatin A and HC-toxin in T47D human breast cancer cells. Arch Pharm Res. 2004 Jun;27(6):640-5.

Density	1.3±0.1 g/cm3
Boiling Point	819.2±65.0 °C at 760 mmHg
Molecular Formula	C₂₁H₃₂N₄O₆
Molecular Weight	436.50
Flash Point	449.2±34.3 °C
Exact Mass	436.232178
PSA	137.21000
LogP	-2.99
Vapour Pressure	0.0±3.0 mmHg at 25°C
Index of Refraction	1.562

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H300
Precautionary Statements	P264-P301 + P310
Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	UN 2811 6.1 / PGIII