21339-55-9

21339-55-9 structure

Name: (S)-Indoximod
Chemical Name: (2S)-2-amino-3-(1-methylindol-3-yl)propanoic acid
CAS Number: 21339-55-9
Molecular Formula: C₁₂H₁₄N₂O₂
Molecular Weight: 218.252
Catalog: Biochemical Chinese herbal medicine ingredients
Create Date: 2018-02-10 08:00:00
Modify Date: 2024-01-02 19:24:38
(S)-Indoximod (1-Methyl-L-tryptophan) is an inhibitor of indoleamine 2,3-dioxygenase (IDO). (S)-Indoximod can be used for the research of cancer[1][2].

Name	(2S)-2-amino-3-(1-methylindol-3-yl)propanoic acid
Synonyms	1-Methyl-L-tryptophan DL-1-Methyltryptophan MFCD00467133 L-Tryptophan, 1-methyl- 1-methyl-(D,L)-tryptophan 1-Methyl-L-tryptophane H-L-Trp(N-CH3)-OH H-Trp(1-Me)-OH BIDD:GT0440 (S)-2-Amino-3-(1-methyl-1H-indol-3-yl)propanoic acid

Description	(S)-Indoximod (1-Methyl-L-tryptophan) is an inhibitor of indoleamine 2,3-dioxygenase (IDO). (S)-Indoximod can be used for the research of cancer[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Indoleamine 2,3-Dioxygenase (IDO)
Target	Indoleamine 2,3-Dioxygenase (IDO)[1]
References	[1]. Huang GL, et, al. PEG-Poly(1-Methyl-l-Tryptophan)-Based Polymeric Micelles as Enzymatically Activated Inhibitors of Indoleamine 2,3-Dioxygenase. Nanomaterials (Basel). 2019 May 9;9(5):719. [2]. Liu X, et, al. 1-L-MT, an IDO inhibitor, prevented colitis-associated cancer by inducing CDC20 inhibition-mediated mitotic death of colon cancer cells. Int J Cancer. 2018 Sep 15;143(6):1516-1529.

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- Volume(issue)/page/year: 1,515,1976

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xn
Risk Phrases	R20/21/22
Safety Phrases	36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	YN7135000
HS Code	2933990090

73-22-3

74-88-4

~92%

21339-55-9

Literature: He, Bin; Song, Hao; Du, Yu; Qin, Yong Journal of Organic Chemistry, 2009 , vol. 74, # 1 p. 298 - 304

73-22-3

21339-55-9

Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 17 p. 2471 - 2474

Precursor 2
73-22-3 74-88-4
DownStream 0

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%