Indoleamine 2, 3-dioxygenase (IDO) is an intracellular enzyme that catalyzes the transformation of L-tryptophan to N-formylkynurenine, which is the first and rate-controlling step in the kynurenine pathway. IDO is a rate-limiting enzyme that catalyzes the degradation of tryptophan into kynurenine and is recognized to exert a tolerizing effect on T cells that require tryptophan to proliferate5. IDO also plays an important role in the activation and regulation of functionally quiescent regulatory T cells. IDO is a heme-containing enzyme that catalyzes the oxidative cleavage of 2,3 double bond of indole ring. IDO has the ability to inhibit T-cell activation by tryptophan starvation, whereas T-cell survival and proliferation are regulated by O2 free radicals and kynurenine derivatives. IDO plays a crucial role in autoimmunity,infections and malignancies. Indoleamine-2,3-dioxygenase (IDO) one of the most important immunoregulator enzyme responsible for metabolism of tryptophan as part of Kynurenin pathway. Tryptophan is catabolized in the tumor tissue by the rate-limiting enzyme IDO expressed in tumor cells or antigen presenting cells.


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BMT-297376

BMT-297376, the optimized Linrodostat, is a potent IDO1 inhibitor[1].

  • CAS Number: 2251031-81-7
  • MF: C23H29F2N3O3
  • MW: 433.49
  • Catalog: Indoleamine 2,3-Dioxygenase (IDO)
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

LY-3381916

LY-3381916 is a potent, selective and brain penetrated inhibitor of IDO1 activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1[1].

  • CAS Number: 2166616-75-5
  • MF: C23H25FN2O3
  • MW: 396.45
  • Catalog: Indoleamine 2,3-Dioxygenase (IDO)
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

(S)-Indoximod-d3

(S)-Indoximod-d3 is the deuterium labeled (S)-Indoximod. (S)-Indoximod (1-Methyl-L-tryptophan) is an inhibitor of indoleamine 2,3-dioxygenase (IDO). (S)-Indoximod can be used for the research of cancer[1][2][3].

  • CAS Number: 1801851-87-5
  • MF: C12H11D3N2O2
  • MW: 221.27
  • Catalog: Indoleamine 2,3-Dioxygenase (IDO)
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

IDO-IN-5

IDO-IN-5 (NLG-1489) is an indoleamine 2,3-dioxygenase (IDO) inhibitor extracted from patent WO WO2012142237A1, compound 1489, has an IC50 of 1-10 μM.

  • CAS Number: 1402837-79-9
  • MF: C18H21FN2O2
  • MW: 316.370
  • Catalog: Indoleamine 2,3-Dioxygenase (IDO)
  • Density: 1.4±0.1 g/cm3
  • Boiling Point: 555.4±35.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 289.7±25.9 °C

IDO1-IN-18

IDO1-IN-18 (Compound 14) is a potent inhibitor of IDO1. IDO1-IN-18 has the potential for the research of cancer diseases[1].

  • CAS Number: 2328099-08-5
  • MF: C23H18F4N2O3
  • MW: 446.39
  • Catalog: Indoleamine 2,3-Dioxygenase (IDO)
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

CAY10581

CAY10581, a pyranonaphthoquinone derivative, is a highly specific and reversible uncompetitive IDO Inhibitor with an IC50 of 55 nM[1][2].

  • CAS Number: 1018340-07-2
  • MF: C22H21NO4
  • MW: 363.406
  • Catalog: Indoleamine 2,3-Dioxygenase (IDO)
  • Density: 1.3±0.1 g/cm3
  • Boiling Point: 548.8±50.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 285.7±30.1 °C

NLG919

IDO-IN-7 (NLG-919 analogue) is a a potent IDO1 inhibitor with an IC50 of 38 nM.

  • CAS Number: 1402836-58-1
  • MF: C18H22N2O
  • MW: 282.380
  • Catalog: Indoleamine 2,3-Dioxygenase (IDO)
  • Density: 1.3±0.1 g/cm3
  • Boiling Point: 524.6±33.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 271.1±25.4 °C

1-Isopropyltryptophan

1-Isopropyltryptophan (1-IsoPT) is a IDO1 inhibitor. 1-Isopropyltryptophan decreases the expression of IFN-γ stimulated ID0-1 and ID0-2 mRNA[1].

  • CAS Number: 1219485-46-7
  • MF: C14H18N2O2
  • MW: 246.30
  • Catalog: Indoleamine 2,3-Dioxygenase (IDO)
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

IDO1-IN-11

IDO1-IN-11 is an IDO1 inhibitor with an IC50 value of 0.6 nM.

  • CAS Number: 2306411-34-5
  • MF: C22H17ClFN3O3
  • MW: 425.84
  • Catalog: Indoleamine 2,3-Dioxygenase (IDO)
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

IACS-8968

IACS-8968 is a dual IDO and TDO inhibitor, with pIC50s of 6.43 for IDO and <5 for TDO, respectively.

  • CAS Number: 2144425-14-7
  • MF: C17H18F3N5O2
  • MW: 381.35
  • Catalog: Indoleamine 2,3-Dioxygenase (IDO)
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

IDO1/TDO-IN-3

IDO1/TDO-IN-3 is a potent inhibitor of IDO1/TDO. IDO1/TDO-IN-3 exhibits significant activities against IDO1 (IC50: 0.005 μM) and TDO (IC50: 0.004 μM). IDO1/TDO-IN-3 shows considerable in vivo anti-tumor activity and no obvious toxicity is observed[1].

  • CAS Number: 2347579-03-5
  • MF: C16H6ClF2N3O2
  • MW: 345.69
  • Catalog: Indoleamine 2,3-Dioxygenase (IDO)
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

IDO1/TDO-IN-6

IDO1/TDO-IN-6 (compound 11) is a dual inhibitor of IDO1/TDO with IC50s of 2.25 and 2.89 μM, respectively. IDO1/TDO-IN-6 has inhibitory effects on IDO1 and TDO, with Ki values of 1.9 and 3.1 μM, respectively. IDO1/TDO-IN-6 can be used in cancer and immunology research[1].

  • CAS Number: 2948772-71-0
  • MF: C20H17NO5
  • MW: 351.35
  • Catalog: Indoleamine 2,3-Dioxygenase (IDO)
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

IDO1-IN-2

IDO1-IN-2 (compound 16) is a potent and selective IDO1 inhibitor with IC50s of 81 nM, 59 nM (mouse) and 28 nM (rat), respectively. IDO1-IN-2 has anti-cancer activity[1].

  • CAS Number: 2346614-58-0
  • MF: C15H17FN6O4
  • MW: 364.33
  • Catalog: Indoleamine 2,3-Dioxygenase (IDO)
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

HI5

HI5 is a potent tublin and IDO inhibitor, with an IC50 value of 70 nM in HeLa cells. HI5 inhibit IDO expression and decrease kynurenine production, leading to stimulating T cells activation and proliferation. HI5 can inhibit tubulin polymerization and cell migration, cause G2/M phase arrest, and induce apoptosis via the mitochondrial dependent apoptosis pathway and cause reactive oxidative stress generation in HeLa cells. HI5 can be used for researching anticancer[1].

  • CAS Number: 2411548-90-6
  • MF: C42H43N5O8
  • MW: 745.82
  • Catalog: Apoptosis
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

IDO1-IN-22

IDO1-IN-22 (Compound 3) is a IDO1 inhibitor (biochemical hIDO1 IC50: 67.4 nM, HeLa hIDO1 IC50: 17.6 nM). IDO1-IN-22 has excellent antitumor efficacy in LLC xenograft model, as well as desirable pharmacokinetic (PK) profile[1].

  • CAS Number: 2126853-16-3
  • MF: C12H12BrFN6O3
  • MW: 387.16
  • Catalog: Indoleamine 2,3-Dioxygenase (IDO)
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Epacadostat(INCB024360)

Epacadostat (INCB 024360) is a potent and selective indoleamine 2,3-dioxigenase 1 (IDO1) inhibitor with an IC50 of 71.8 nM.

  • CAS Number: 1204669-58-8
  • MF: C11H13BrFN7O4S
  • MW: 438.233
  • Catalog: Indoleamine 2,3-Dioxygenase (IDO)
  • Density: 2.0±0.1 g/cm3
  • Boiling Point: 672.3±65.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 360.4±34.3 °C

IDO antagonist-1

IDO antagonist-1 (compound 163) is an antagonist of IDO . IDO antagonist-1 inhibits pancreatic adenocarcinoma cells growth in C57BL/6 mice[1].

  • CAS Number: 2206797-88-6
  • MF: C39H53N7O5
  • MW: 699.88
  • Catalog: Indoleamine 2,3-Dioxygenase (IDO)
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

IDO-IN-4

IDO-IN-4 is an indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor, extracted from patent WO2014150677A1, Compound example 1 enantiomer 1.

  • CAS Number: 1629125-65-0
  • MF: C26H35N3O3
  • MW: 437.574
  • Catalog: Indoleamine 2,3-Dioxygenase (IDO)
  • Density: 1.2±0.1 g/cm3
  • Boiling Point: 532.6±50.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 275.9±30.1 °C

IDO-IN-18

IDO-IN-18 (Compound 00815) is an IDO inhibitor. IDO-IN-18 can be used for research of immunosuppression associated infectious or cancer diseases[1].

  • CAS Number: 314027-92-4
  • MF: C10H8N2O2S
  • MW: 220.25
  • Catalog: Indoleamine 2,3-Dioxygenase (IDO)
  • Density: 1.5±0.1 g/cm3
  • Boiling Point: 526.6±30.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 272.3±24.6 °C

Linrodostat (BMS-986205)

BMS-986205 is a selective indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor.

  • CAS Number: 1923833-60-6
  • MF: C24H24ClFN2O
  • MW: 410.15
  • Catalog: Indoleamine 2,3-Dioxygenase (IDO)
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

(Rac)-Indoximod

(Rac)-Indoximod (1-Methyl-DL-tryptophan) is an indoleamine 2,3-dioxygenase (IDO) inhibitor. Co-treatment with IFN-γ and (Rac)-Indoximod markedly reduces the activity of human cardiac myofibroblasts (hCMs) expressing α-SMA and induces apoptosis through up-regulating the IRF-1, Fas, and FasL genes[1].

  • CAS Number: 26988-72-7
  • MF: C12H14N2O2
  • MW: 218.25200
  • Catalog: Indoleamine 2,3-Dioxygenase (IDO)
  • Density: 1.28g/cm3
  • Boiling Point: 429.3ºC at 760mmHg
  • Melting Point: 250ºC (dec.)(lit.)
  • Flash Point: 213.4ºC

1H-Naphtho(2,3-d)-1,2,3-triazole-4,9-dione, 1-phenyl-

IDO1/TDO-IN-2 (Compound 1) is a potent inhibitor of IDO1/TDO with IC50s of 0.1 and 0.07 μM. IDO1/TDO-IN-2 has the potential for the research of cancer diseases[1].

  • CAS Number: 5466-47-7
  • MF: C16H9N3O2
  • MW: 275.26
  • Catalog: Indoleamine 2,3-Dioxygenase (IDO)
  • Density: 1.44g/cm3
  • Boiling Point: 523.4ºC at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 270.3ºC

NLG802

NLG802 is a prodrug of indoximod, an orally active indoleamine 2,3-dioxygenase (IDO) inhibitor.

  • CAS Number: 2071683-99-1
  • MF: C20H30ClN3O3
  • MW: 395.92
  • Catalog: Indoleamine 2,3-Dioxygenase (IDO)
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

IDO1/2-IN-1 hydrochloride

IDO1/2-IN-1 hydrochloride (compound 4t) is the first potent IDO1/IDO2 dual inhibitor with IC50s of 28 nM and 144 nM for IDO1 and IDO2, respectively. IDO1/2-IN-1 hydrochloride exhibits antitumor activies. Orally active[1].

  • CAS Number: 2310286-60-1
  • MF: C16H19BrClFN8O4
  • MW: 521.73
  • Catalog: Indoleamine 2,3-Dioxygenase (IDO)
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

IDO-IN-2

IDO-IN-2 is an IDO inhibitor extracted from patent WO/2015031295 A1, compound example 1, has IC50 values of 0.068 μM in HeLa cell and 0.16 μM in HEK293 cell.

  • CAS Number: 1668565-74-9
  • MF: C29H35N7O
  • MW: 497.63
  • Catalog: Indoleamine 2,3-Dioxygenase (IDO)
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

IDO1/TDO-IN-1

IDO1/TDO-IN-1 (30) is a potent dual IDO1 (uncompetitive, Ki of 0.23 μM) and TDO (competitive, Ki of 0.73 μM) inhibitor. IDO1/TDO-IN-1 (30) significantly promotes cell apoptosis through the potential mitochondria-mediated Bcl-2/Bax pathway[1].

  • CAS Number: 2379527-72-5
  • MF: C21H16O6
  • MW: 364.35
  • Catalog: Apoptosis
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

(S)-Indoximod

(S)-Indoximod (1-Methyl-L-tryptophan) is an inhibitor of indoleamine 2,3-dioxygenase (IDO). (S)-Indoximod can be used for the research of cancer[1][2].

  • CAS Number: 21339-55-9
  • MF: C12H14N2O2
  • MW: 218.252
  • Catalog: Indoleamine 2,3-Dioxygenase (IDO)
  • Density: 1.28
  • Boiling Point: 429.3±35.0 °C at 760 mmHg
  • Melting Point: 223-226 ºC
  • Flash Point: 213.4±25.9 °C

IACS-8968 R-enantiomer

IACS-8968 (R-enantiomer) is the R-enantiomer of IACS-8968. IACS-8968 is a dual IDO and TDO inhibitor, with pIC50s of 6.43 for IDO and <5 for TDO, respectively.

  • CAS Number: 2239305-67-8
  • MF: C17H18F3N5O2
  • MW: 381.35
  • Catalog: Indoleamine 2,3-Dioxygenase (IDO)
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

4-Phenyl-1H-1,2,3-triazole

4-Phenyl-1H-1,2,3-triazole is an IDO1 inhibitor (IC50: 60 渭M). 4-Phenyl-1H-1,2,3-triazole can be used for cancer research[1].

  • CAS Number: 1680-44-0
  • MF: C8H7N3
  • MW: 145.16
  • Catalog: Indoleamine 2,3-Dioxygenase (IDO)
  • Density: 1.2±0.1 g/cm3
  • Boiling Point: 346.0±11.0 °C at 760 mmHg
  • Melting Point: 143-14℃
  • Flash Point: 169.4±12.2 °C

IDO1-IN-17

IDO1-IN-17 (I-4) is an IDO1 inhibitor, with an IC50 of 0.44 μM in hela cells[1].

  • CAS Number: 2677054-58-7
  • MF: C28H32BrClFN5O2
  • MW: 604.94
  • Catalog: Indoleamine 2,3-Dioxygenase (IDO)
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A