Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 7-Methoxycoumarin
Price: Check
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang
Email: sales@echemcloud.com

BioBioPha
China
Product Name: 7-Methoxycoumarin
Price: ￥Inquiry/5mg
Purity: 98.0%
Stocking Period: 10 Day
Contact: Xueping-Zheng
Email: 1477035482@qq.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: 7-Methoxycoumarin
Price: ￥118.0/20mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Liu jia
Email: 2130147988@qq.com

DC Chemicals Limited
China
Product Name: 7-Methoxycoumarin
Price: $280.0/20mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 7-Methoxycoumarin
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

531-59-9

531-59-9 structure

531-59-9 structure

Name: 7-Methoxycoumarin
Chemical Name: herniarin
CAS Number: 531-59-9
Molecular Formula: C₁₀H₈O₃
Molecular Weight: 176.169
Catalog: Biochemical Plant extracts
Create Date: 2018-04-24 08:00:00
Modify Date: 2025-08-20 20:40:15
Herniarin is a natural coumarin occurs in some flowering plants, with antitumor effect.

Name	herniarin
Synonyms	Coumarin, 7-methoxy- Herniarin 7-Methoxycoumarin Coumarin, 7-methoxy- (8CI) Methyl umbelliferyl ether EINECS 208-513-3 7-methoxychromen-2-one 7-Methoxy-2H-chromen-2-one 2H-1-Benzopyran-2-one, 7-methoxy- Herniarin (6CI) MFCD00006876

Description	Herniarin is a natural coumarin occurs in some flowering plants, with antitumor effect.
Related Catalog	Signaling Pathways >> Others >> Others Natural Products >> Phenylpropanoids Research Areas >> Cancer
In Vitro	Herniarin is cytotoxic to breast carcinoma cell line MCF-7 with an IC50 of 207.6 µM. Herniarin (100 µM) also induces apoptosis in MCF-7 cells[1]. Herniarin alone has no obvious cytotoxicity on transitional cell carcinoma (TCC) cells, but when in combination with 5 µg/mL cisplatin, Herniarin (80 µg/mL) potently enhances the antitumor effect of cisplatin, and increases chromatin condensation[2].
Cell Assay	Briefly, the cells are seeded (104 cells per well) onto flat-bottomed 96-well culture plates and allowed to grow 72 h after treatment with various concentration of auraptene, Herniarin, umbelliferone, and umbelliprenin. After removing the medium, MTT solution (5 mg/mL in PBS) is added and incubated for 4 h and the resulting formazan is solubilized with DMSO (100 mL). The absorption is measured at 570 nm (620 nm as a reference) in an ELISA reader[1].
References	[1]. Mousavi SH, et al. Comparative analysis of the cytotoxic effect of 7-prenyloxycoumarin compounds and herniarin on MCF-7 cell line. Avicenna J Phytomed. 2015 Nov-Dec;5(6):520-30. [2]. Haghighitalab A, et al. Enhancement of cisplatin cytotoxicity in combination with herniarin in vitro. Drug Chem Toxicol. 2014 Apr;37(2):156-62.

Density	1.2±0.1 g/cm3
Boiling Point	335.3±37.0 °C at 760 mmHg
Melting Point	117-121 °C(lit.)
Molecular Formula	C₁₀H₈O₃
Molecular Weight	176.169
Flash Point	138.6±21.1 °C
Exact Mass	176.047348
PSA	39.44000
LogP	1.78
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.572
Water Solubility	MISCIBLE

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DJ3100380

CHEMICAL NAME :: 2H-1-Benzopyran-2-one, 7-methoxy-

CAS REGISTRY NUMBER :: 531-59-9

BEILSTEIN REFERENCE NO. :: 0141728

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C10-H8-O3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 26,375,1988

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 26,375,1988

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
Risk Phrases	36/37/38
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	DJ3100380
HS Code	2932209090

Precursor 8
93-35-6 77-78-1 74-88-4 150-19-6
623-47-2 673-22-3 4279-77-0 141-32-2
DownStream 10
108530-10-5 50551-61-6 20921-02-2 93-35-6
2555-28-4 139386-27-9 15399-67-4 17598-02-6
11037-15-3 2555-22-8

HS Code	2932209090
Summary	2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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