7-Methoxycoumarin

Modify Date: 2025-08-20 20:40:15

7-Methoxycoumarin structure	Common Name	7-Methoxycoumarin
	CAS Number	531-59-9	Molecular Weight	176.169
	Density	1.2±0.1 g/cm3	Boiling Point	335.3±37.0 °C at 760 mmHg
	Molecular Formula	C₁₀H₈O₃	Melting Point	117-121 °C(lit.)
	MSDS	Chinese USA	Flash Point	138.6±21.1 °C

Use of 7-Methoxycoumarin

Herniarin is a natural coumarin occurs in some flowering plants, with antitumor effect.

Name	herniarin
Synonym	More Synonyms

Description	Herniarin is a natural coumarin occurs in some flowering plants, with antitumor effect.
Related Catalog	Signaling Pathways >> Others >> Others Natural Products >> Phenylpropanoids Research Areas >> Cancer
In Vitro	Herniarin is cytotoxic to breast carcinoma cell line MCF-7 with an IC50 of 207.6 µM. Herniarin (100 µM) also induces apoptosis in MCF-7 cells[1]. Herniarin alone has no obvious cytotoxicity on transitional cell carcinoma (TCC) cells, but when in combination with 5 µg/mL cisplatin, Herniarin (80 µg/mL) potently enhances the antitumor effect of cisplatin, and increases chromatin condensation[2].
Cell Assay	Briefly, the cells are seeded (104 cells per well) onto flat-bottomed 96-well culture plates and allowed to grow 72 h after treatment with various concentration of auraptene, Herniarin, umbelliferone, and umbelliprenin. After removing the medium, MTT solution (5 mg/mL in PBS) is added and incubated for 4 h and the resulting formazan is solubilized with DMSO (100 mL). The absorption is measured at 570 nm (620 nm as a reference) in an ELISA reader[1].
References	[1]. Mousavi SH, et al. Comparative analysis of the cytotoxic effect of 7-prenyloxycoumarin compounds and herniarin on MCF-7 cell line. Avicenna J Phytomed. 2015 Nov-Dec;5(6):520-30. [2]. Haghighitalab A, et al. Enhancement of cisplatin cytotoxicity in combination with herniarin in vitro. Drug Chem Toxicol. 2014 Apr;37(2):156-62.

Density	1.2±0.1 g/cm3
Boiling Point	335.3±37.0 °C at 760 mmHg
Melting Point	117-121 °C(lit.)
Molecular Formula	C₁₀H₈O₃
Molecular Weight	176.169
Flash Point	138.6±21.1 °C
Exact Mass	176.047348
PSA	39.44000
LogP	1.78
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.572
Water Solubility	MISCIBLE

7-Methoxycoumarin MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DJ3100380

CHEMICAL NAME :: 2H-1-Benzopyran-2-one, 7-methoxy-

CAS REGISTRY NUMBER :: 531-59-9

BEILSTEIN REFERENCE NO. :: 0141728

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C10-H8-O3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 26,375,1988

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 26,375,1988

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
Risk Phrases	36/37/38
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	DJ3100380
HS Code	2932209090

Precursor 8
CAS#:93-35-6 7-Hydroxycoumarine CAS#:77-78-1 Dimethyl sulfate CAS#:74-88-4 methyl iodide CAS#:150-19-6 m-Methoxyphenol
CAS#:623-47-2 Ethyl propiolate CAS#:673-22-3 2-Hydroxy-4-met... CAS#:4279-77-0 3-oxo-3-phenyls... CAS#:141-32-2 butyl acrylate
DownStream 10
CAS#:108530-10-5 2-Oxo-2H-chrome... CAS#:50551-61-6 6-METHOXYBENZOF... CAS#:20921-02-2 7-methoxy-3,4-d... CAS#:93-35-6 7-Hydroxycoumarine
CAS#:2555-28-4 7-Methoxy-4-met... CAS#:139386-27-9 Ethyl (E)-3-(2-... CAS#:15399-67-4 2-(2-aminopropa... CAS#:17598-02-6 2H-1-Benzopyran...
CAS#:11037-15-3 2-Isopropenyl-7... CAS#:2555-22-8 7-Methoxy-3-phe...

HS Code	2932209090
Summary	2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Non-animal photosafety screening for complex cosmetic ingredients with photochemical and photobiochemical assessment tools.

Regul Toxicol Pharmacol 72 , 578-85, (2015)

Previously, a non-animal screening approach was proposed for evaluating photosafety of cosmetic ingredients by means of in vitro photochemical and photobiochemical assays; however, complex cosmetic in...

An efficient and economical MTT assay for determining the antioxidant activity of plant natural product extracts and pure compounds.

J. Nat. Prod. 73 , 1193-5, (2010)

Antioxidants scavenge free radicals, singlet oxygen, and electrons in cellular redox reactions. The yellow MTT [3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide] is reduced to a purple fo...

7-substituted coumarins inhibit proliferation and migration of laryngeal cancer cells in vitro.

Anticancer Res. 33(10) , 4347-56, (2013)

Coumarins are a large group of naturally-occurring compounds with a wide range of biological properties, including anticancer activity. 7-Substituted coumarins (umbelliferone, scoparone, and herniarin...

Coumarin, 7-methoxy-

Herniarin

7-Methoxycoumarin

Coumarin, 7-methoxy- (8CI)

Methyl umbelliferyl ether

EINECS 208-513-3

7-methoxychromen-2-one

7-Methoxy-2H-chromen-2-one

2H-1-Benzopyran-2-one, 7-methoxy-

Herniarin (6CI)

MFCD00006876

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 7-Methoxycoumarin
Price: Check
Purity: 98.0%
Delivery: 10 Day
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BioBioPha
China
Product Name: 7-Methoxycoumarin
Price: ￥Inquiry/5mg
Purity: 98.0%
Delivery: 10 Day
Contact: Xueping-Zheng
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: 7-Methoxycoumarin
Price: ￥118.0/20mg
Purity: 98.0%
Delivery: 1 Day
Contact: Liu jia
Email: 2130147988@qq.com

DC Chemicals Limited
China
Product Name: 7-Methoxycoumarin
Price: $280.0/20mg
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 7-Methoxycoumarin
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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7-Methoxycoumarin

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