293762-45-5

293762-45-5 structure

Name: Ro 90-7501
Chemical Name: 2-[2-(4-aminophenyl)-3H-benzimidazol-5-yl]-3H-benzimidazol-5-amine
CAS Number: 293762-45-5
Molecular Formula: C₂₀H₁₆N₆
Molecular Weight: 340.38100
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2017-09-15 23:04:59
Modify Date: 2024-01-06 06:39:17
Ro 90-7501 is an amyloid β42 (Aβ42) fibril assembly inhibitor that reduces Aβ42-induced cytotoxicity (EC50 of 2 μM). Ro 90-7501 inhibits ATM phosphorylation and DNA repair. RO 90-7501 selectively enhances toll-like receptor 3 (TLR3) and RIG-I-like receptor (RLR) ligand-induced IFN-β gene expression and antiviral response[2]. Ro 90-7501 also inhibits protein phosphatase 5 (PP5) in a TPR-dependent manner[3]. Ro 90-7501 has significant radiosensitizing effects on cervical cancer cells[4].

Name	2-[2-(4-aminophenyl)-3H-benzimidazol-5-yl]-3H-benzimidazol-5-amine
Synonyms	Ro 90-7501 2'-(4-Aminophenyl)-[2,5'-bi-1H-benzimidazol]-5-amine GNF-Pf-5510

Description	Ro 90-7501 is an amyloid β42 (Aβ42) fibril assembly inhibitor that reduces Aβ42-induced cytotoxicity (EC50 of 2 μM). Ro 90-7501 inhibits ATM phosphorylation and DNA repair. RO 90-7501 selectively enhances toll-like receptor 3 (TLR3) and RIG-I-like receptor (RLR) ligand-induced IFN-β gene expression and antiviral response[2]. Ro 90-7501 also inhibits protein phosphatase 5 (PP5) in a TPR-dependent manner[3]. Ro 90-7501 has significant radiosensitizing effects on cervical cancer cells[4].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> ATM/ATR Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase Signaling Pathways >> PI3K/Akt/mTOR >> ATM/ATR Research Areas >> Neurological Disease
Target	Amyloid β42 ATM Protein phosphatase 5 Apoptosis
In Vitro	Ro 90-7501 significantly enhances radiosensitivity compared with control HeLa and ME-180 cells. Ro 90-7501 significantly increases apoptosis and impaired cell cycle after irradiation. Ro 90-7501 suppresses the phosphorylation of ATM and its downstream proteins, such as H2AX, Chk1, and Chk2, after irradiation[1]. RO 90-7501, itself affects neither IFN-β nor NFκB promoter activity, but significantly enhances poly I:C-induced IFN-β promoter activation and inhibits the activation of NFκB in a dose-dependent manner. Treatment of cells with RO 90-7501 significantly enhances the antiviral activity of poly I:C[2].
In Vivo	Ro 90-7501 (5 μg/g; intraperitoneal injection; daily; for 21 days; female BALB/c nude mice) treatment significantly delays tumor growth and significantly decreases tumor volume[1]. Animal Model: Female BALB/c nude mice (8-week-old) with HeLa cells under irradiation[1] Dosage: 5 μg/g Administration: Intraperitoneal injection; daily; for 21 days Result: Tumor growth was significantly delayed in the combination group. Tumor volume was also significantly decreased in the irradiation group.
References	[1]. Tamari K, et al. Ro 90-7501 Is a Novel Radiosensitizer for Cervical Cancer Cells that Inhibits ATM Phosphorylation. Anticancer Res. 2019 Sep;39(9):4805-4810. [2]. Guo F, et al. RO 90-7501 enhances TLR3 and RLR agonist induced antiviral response. PLoS One. 2012;7(10):e42583. [3]. Hong TJ, et al. Ro 90-7501 inhibits PP5 through a novel, TPR-dependent mechanism. Biochem Biophys Res Commun. 2017 Jan 8;482(2):215-220. [4]. Bohrmann B, et al. Self-assembly of beta-amyloid 42 is retarded by small molecular ligands at the stage of structural intermediates. J Struct Biol. 2000 Jun;130(2-3):232-46.

Density	1.443g/cm3
Boiling Point	751.035ºC at 760 mmHg
Molecular Formula	C₂₀H₁₆N₆
Molecular Weight	340.38100
Flash Point	449.122ºC
Exact Mass	340.14400
PSA	109.40000
LogP	5.10000
Vapour Pressure	0mmHg at 25°C
Index of Refraction	1.842

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi
Risk Phrases	36/37/38
Safety Phrases	26-36/37
RIDADR	NONH for all modes of transport

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