40600-13-3

40600-13-3 structure
40600-13-3 structure
  • Name: Cirazoline hydrochloride
  • Chemical Name: 2-[(2-cyclopropylphenoxy)methyl]-4,5-dihydro-1H-imidazole,hydrochloride
  • CAS Number: 40600-13-3
  • Molecular Formula: C13H17ClN2O
  • Molecular Weight: 252.74000
  • Catalog: Signaling Pathways GPCR/G Protein Adenosine Receptor
  • Create Date: 2018-07-12 09:29:51
  • Modify Date: 2024-01-05 10:45:40
  • Cirazoline hydrochloride (LD 3098 hydrochloride) is a potent competitive full α1A-adrenergic receptor (α1A-AR) agonist (Ki=120 nM) and only a partial agonist at α1B-AR (Ki= 960 nM) and α1D-AR (Ki=660 nM)[1].

Name 2-[(2-cyclopropylphenoxy)methyl]-4,5-dihydro-1H-imidazole,hydrochloride
Synonyms 2-[(2-Cyclopropylphenoxy)methyl]-4,5-dihydro-1H-imidazole hydrochloride
Cirazoline HCl
Phenserine
EINECS 254-995-3
Cirazoline hydrochloride
MFCD00274034
Description Cirazoline hydrochloride (LD 3098 hydrochloride) is a potent competitive full α1A-adrenergic receptor (α1A-AR) agonist (Ki=120 nM) and only a partial agonist at α1B-AR (Ki= 960 nM) and α1D-AR (Ki=660 nM)[1].
Related Catalog
In Vitro Cirazoline hydrochloride (5-10 μM; 24 hours) does not alter GIC survival and counteracted only poorly prazosin‐induced GIC death[1]. Cell Viability Assay[1] Cell Line: Glioblastoma‐initiating cells Concentration: 5 μM; 10 μM Incubation Time: 24 hours Result: Did not effect GIC cell survival.
In Vivo Cirazoline hydrochloride (drinking water; 40 μM; 9 month) exhibits significantly decreased immobility in the TST and enhances neurogenesis in the mouse[1]. Animal Model: B6/CBA mice[1] Dosage: 40 μM Administration: Drinking water; 40 μM; 9 month Result: Reversed antidepressant-like phenotype of CAM α1A-AR Mice .
References

[1]. Doze VA, et al. alpha(1A)- and alpha(1B)-adrenergic receptors differentially modulate antidepressant-like behaviorin the mouse.Brain Res. 2009 Aug 18;1285:148-57.

[2]. Suzana Assad Kahn , et al. The Anti-Hypertensive Drug Prazosin Inhibits Glioblastoma Growth via the PKCδ-dependent Inhibition of the AKT Pathway. EMBO Mol Med. 2016 May 2;8(5):511-26.

Density 1.25g/cm3
Boiling Point 409.5ºC at 760mmHg
Molecular Formula C13H17ClN2O
Molecular Weight 252.74000
Flash Point 201.4ºC
Exact Mass 252.10300
PSA 33.62000
LogP 2.51090
Storage condition 2-8°C
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases S22-S24/25
RIDADR NONH for all modes of transport