40600-13-3

40600-13-3 structure

Name: Cirazoline hydrochloride
Chemical Name: 2-[(2-cyclopropylphenoxy)methyl]-4,5-dihydro-1H-imidazole,hydrochloride
CAS Number: 40600-13-3
Molecular Formula: C₁₃H₁₇ClN₂O
Molecular Weight: 252.74000
Catalog: Signaling Pathways GPCR/G Protein Adenosine Receptor
Create Date: 2018-07-12 09:29:51
Modify Date: 2024-01-05 10:45:40
Cirazoline hydrochloride (LD 3098 hydrochloride) is a potent competitive full α1A-adrenergic receptor (α1A-AR) agonist (Ki=120 nM) and only a partial agonist at α1B-AR (Ki= 960 nM) and α1D-AR (Ki=660 nM)[1].

Name	2-[(2-cyclopropylphenoxy)methyl]-4,5-dihydro-1H-imidazole,hydrochloride
Synonyms	2-[(2-Cyclopropylphenoxy)methyl]-4,5-dihydro-1H-imidazole hydrochloride Cirazoline HCl Phenserine EINECS 254-995-3 Cirazoline hydrochloride MFCD00274034

Description	Cirazoline hydrochloride (LD 3098 hydrochloride) is a potent competitive full α1A-adrenergic receptor (α1A-AR) agonist (Ki=120 nM) and only a partial agonist at α1B-AR (Ki= 960 nM) and α1D-AR (Ki=660 nM)[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor
In Vitro	Cirazoline hydrochloride (5-10 μM; 24 hours) does not alter GIC survival and counteracted only poorly prazosin‐induced GIC death[1]. Cell Viability Assay[1] Cell Line: Glioblastoma‐initiating cells Concentration: 5 μM; 10 μM Incubation Time: 24 hours Result: Did not effect GIC cell survival.
In Vivo	Cirazoline hydrochloride (drinking water; 40 μM; 9 month) exhibits significantly decreased immobility in the TST and enhances neurogenesis in the mouse[1]. Animal Model: B6/CBA mice[1] Dosage: 40 μM Administration: Drinking water; 40 μM; 9 month Result: Reversed antidepressant-like phenotype of CAM α1A-AR Mice .
References	[1]. Doze VA, et al. alpha(1A)- and alpha(1B)-adrenergic receptors differentially modulate antidepressant-like behaviorin the mouse.Brain Res. 2009 Aug 18;1285:148-57. [2]. Suzana Assad Kahn , et al. The Anti-Hypertensive Drug Prazosin Inhibits Glioblastoma Growth via the PKCδ-dependent Inhibition of the AKT Pathway. EMBO Mol Med. 2016 May 2;8(5):511-26.

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport