Name | 2-[(2-cyclopropylphenoxy)methyl]-4,5-dihydro-1H-imidazole,hydrochloride |
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Synonyms |
2-[(2-Cyclopropylphenoxy)methyl]-4,5-dihydro-1H-imidazole hydrochloride
Cirazoline HCl Phenserine EINECS 254-995-3 Cirazoline hydrochloride MFCD00274034 |
Description | Cirazoline hydrochloride (LD 3098 hydrochloride) is a potent competitive full α1A-adrenergic receptor (α1A-AR) agonist (Ki=120 nM) and only a partial agonist at α1B-AR (Ki= 960 nM) and α1D-AR (Ki=660 nM)[1]. |
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Related Catalog | |
In Vitro | Cirazoline hydrochloride (5-10 μM; 24 hours) does not alter GIC survival and counteracted only poorly prazosin‐induced GIC death[1]. Cell Viability Assay[1] Cell Line: Glioblastoma‐initiating cells Concentration: 5 μM; 10 μM Incubation Time: 24 hours Result: Did not effect GIC cell survival. |
In Vivo | Cirazoline hydrochloride (drinking water; 40 μM; 9 month) exhibits significantly decreased immobility in the TST and enhances neurogenesis in the mouse[1]. Animal Model: B6/CBA mice[1] Dosage: 40 μM Administration: Drinking water; 40 μM; 9 month Result: Reversed antidepressant-like phenotype of CAM α1A-AR Mice . |
References |
Density | 1.25g/cm3 |
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Boiling Point | 409.5ºC at 760mmHg |
Molecular Formula | C13H17ClN2O |
Molecular Weight | 252.74000 |
Flash Point | 201.4ºC |
Exact Mass | 252.10300 |
PSA | 33.62000 |
LogP | 2.51090 |
Storage condition | 2-8°C |
Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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Safety Phrases | S22-S24/25 |
RIDADR | NONH for all modes of transport |