Cirazoline hydrochloride
Cirazoline hydrochloride structure
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Common Name | Cirazoline hydrochloride | ||
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| CAS Number | 40600-13-3 | Molecular Weight | 252.74000 | |
| Density | 1.25g/cm3 | Boiling Point | 409.5ºC at 760mmHg | |
| Molecular Formula | C13H17ClN2O | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 201.4ºC | |
Use of Cirazoline hydrochlorideCirazoline hydrochloride (LD 3098 hydrochloride) is a potent competitive full α1A-adrenergic receptor (α1A-AR) agonist (Ki=120 nM) and only a partial agonist at α1B-AR (Ki= 960 nM) and α1D-AR (Ki=660 nM)[1]. |
| Name | 2-[(2-cyclopropylphenoxy)methyl]-4,5-dihydro-1H-imidazole,hydrochloride |
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| Synonym | More Synonyms |
| Description | Cirazoline hydrochloride (LD 3098 hydrochloride) is a potent competitive full α1A-adrenergic receptor (α1A-AR) agonist (Ki=120 nM) and only a partial agonist at α1B-AR (Ki= 960 nM) and α1D-AR (Ki=660 nM)[1]. |
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| Related Catalog | |
| In Vitro | Cirazoline hydrochloride (5-10 μM; 24 hours) does not alter GIC survival and counteracted only poorly prazosin‐induced GIC death[1]. Cell Viability Assay[1] Cell Line: Glioblastoma‐initiating cells Concentration: 5 μM; 10 μM Incubation Time: 24 hours Result: Did not effect GIC cell survival. |
| In Vivo | Cirazoline hydrochloride (drinking water; 40 μM; 9 month) exhibits significantly decreased immobility in the TST and enhances neurogenesis in the mouse[1]. Animal Model: B6/CBA mice[1] Dosage: 40 μM Administration: Drinking water; 40 μM; 9 month Result: Reversed antidepressant-like phenotype of CAM α1A-AR Mice . |
| References |
| Density | 1.25g/cm3 |
|---|---|
| Boiling Point | 409.5ºC at 760mmHg |
| Molecular Formula | C13H17ClN2O |
| Molecular Weight | 252.74000 |
| Flash Point | 201.4ºC |
| Exact Mass | 252.10300 |
| PSA | 33.62000 |
| LogP | 2.51090 |
| Storage condition | 2-8°C |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| Safety Phrases | S22-S24/25 |
| RIDADR | NONH for all modes of transport |
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The contribution of d-tubocurarine-sensitive and apamin-sensitive K-channels to EDHF-mediated relaxation of mesenteric arteries from eNOS-/- mice.
J. Cardiovasc. Pharmacol. 59(5) , 413-25, (2012) The nature of the potassium channels involved in determining endothelium-derived hyperpolarizing factor-mediated relaxation was investigated in first-order small mesenteric arteries from male endothel... |
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Different response of ANP secretion to adrenoceptor stimulation in renal hypertensive rat atria.
Peptides 29(7) , 1207-15, (2008) Sympathetic nervous system and atrial natriuretic peptide (ANP) system play fundamental roles in the regulation of cardiovascular functions. Overactivity of sympathetic nervous system can lead into ca... |
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Attenuation of store-operated Ca2+ entry and enhanced expression of TRPC channels in caudal artery smooth muscle from Type 2 diabetic Goto-Kakizaki rats.
Clin. Exp. Pharmacol. Physiol. 37(7) , 670-8, (2010) 1. Previously, we found that Ca(2+) entry from the extracellular space via alpha(1)-adrenoceptor-activated, Ca(2+)-permeable channels, but not voltage-gated Ca(2+) channels, is impaired in endothelium... |
| 2-[(2-Cyclopropylphenoxy)methyl]-4,5-dihydro-1H-imidazole hydrochloride |
| Cirazoline HCl |
| Phenserine |
| EINECS 254-995-3 |
| Cirazoline hydrochloride |
| MFCD00274034 |