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117830-79-2

117830-79-2 structure
117830-79-2 structure
  • Name: Enterostatin human
  • Chemical Name: (2S)-2-[[(2S)-1-[2-[[(2S)-1-[(2S)-2-aminopropanoyl]pyrrolidine-2-carbonyl]amino]acetyl]pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid
  • CAS Number: 117830-79-2
  • Molecular Formula: C21H36N8O6
  • Molecular Weight: 496.56100
  • Catalog: Peptides
  • Create Date: 2018-07-18 16:16:12
  • Modify Date: 2024-01-02 11:22:11
  • Enterostatin, human, mouse, rat is a pentapeptide that reduces fat intake.
Name (2S)-2-[[(2S)-1-[2-[[(2S)-1-[(2S)-2-aminopropanoyl]pyrrolidine-2-carbonyl]amino]acetyl]pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid
Synonyms CLAP
H-Ala-Pro-Gly-Pro-Arg-OH
Enterostatin human
APGPR
APGPR Enterostatin
Ala-pro-gly-pro-arg
Procolipase activation peptide
ALA-PRO-GLY-PRO-ARG
Enterostatin, human, mouse, rat
Description Enterostatin, human, mouse, rat is a pentapeptide that reduces fat intake.
Related Catalog
Target

Human Endogenous Metabolite
In Vitro In the perfused ratpancreas, Enterostatin, at 100 mM, inhibits the insulin response to 9 mM glucose (by 70%), 0.1 mM tolbutamide (by 40%), and 5 mM arginine (by 70%)[1].
In Vivo Chronically, enterostatin reduces fat intake, bodyweight, and body fat. This response may involve multiple metabolic effects of enterostatin, which include a reduction of insulin secretion, an increase in sympathetic drive to brown adipose tissue, and the stimulation of adrenal corticosteroid secretion[2]. Enterostatin enhances memory consolidation after central or oral administration at a dose of 10 nmol/mouse or 300 mg/kg, respectively, in a step-through type passive avoidance test in mice[3]. A dose of 38 nmol of enterostatin gives a significant inhibition of high-fat food intake, while at a higher dose of 76 nmol the inhibiting effect is lost. During the first hour, after injection of enterostatin, there is even a slight increase in food intake[4].
References

[1]. Silvestre RA, et al. Effect of enterostatin on insulin, glucagon, and somatostatin secretion in the perfused rat pancreas. Diabetes. 1996 Sep;45(9):1157-60.

[2]. Erlanson-Albertsson C, et al. Enterostatin--a peptide regulating fat intake. Obes Res. 1997 Jul;5(4):360-72.

[3]. Ohinata K, et al. Enterostatin (APGPR) enhances memory consolidation in mice. Peptides. 2007 Mar;28(3):719-21.

[4]. Sörhede M, et al. Enterostatin: a gut-brain peptide regulating fat intake in rat. J Physiol Paris. 1993;87(4):273-5.
Density 1.54g/cm3
Molecular Formula C21H36N8O6
Molecular Weight 496.56100
Exact Mass 496.27600
PSA 224.04000
Index of Refraction 1.681
Storage condition -20°C
Hazard Codes Xi

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title: CAS No. 117830-79-2 | Chemsrc address: https://m.chemsrc.com/en/baike/1195178.html

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