148439-49-0

148439-49-0 structure

Name: Prion Protein 106-126 (human)
Chemical Name: PrP [106-126]
CAS Number: 148439-49-0
Molecular Formula: C₈₀H₁₃₈N₂₆O₂₄S₂
Molecular Weight: 1912.24000
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2018-11-11 23:51:45
Modify Date: 2025-08-26 22:08:52
Prion Protein 106-126 (human) is a peptide fragment of prion, it can induct neuronal apoptosis, antiproteinase K digestion, fiber formation, and mediate the conversion of normal cellular prion protein (PrPc) into pathogenic isoform (PrPSc). Prion Protein 106-126 (human) is generally used as the model to investigate neural degeneration of prion disease[1][2].

Name	PrP [106-126]
Synonyms	Prion Protein Fragment 106-126 Human N-MPPP Hydrochloride

Description	Prion Protein 106-126 (human) is a peptide fragment of prion, it can induct neuronal apoptosis, antiproteinase K digestion, fiber formation, and mediate the conversion of normal cellular prion protein (PrPc) into pathogenic isoform (PrPSc). Prion Protein 106-126 (human) is generally used as the model to investigate neural degeneration of prion disease[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Neurological Disease
References	[1]. Forloni G, et, al. Neurotoxicity of a prion protein fragment. Nature. 1993 Apr 8; 362(6420): 543-6. [2]. Hong JM, et, al. Human prion protein-mediated calcineurin activation induces neuron cell death via AMPK and autophagy pathway. Int J Biochem Cell Biol. 2020 Feb; 119: 105680.

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport