Prion Protein 106-126 (human)

Modify Date: 2024-01-02 20:08:10

Prion Protein 106-126 (human) Structure
Prion Protein 106-126 (human) structure
Common Name Prion Protein 106-126 (human)
CAS Number 148439-49-0 Molecular Weight 1912.24000
Density N/A Boiling Point N/A
Molecular Formula C80H138N26O24S2 Melting Point N/A
MSDS USA Flash Point N/A

 Use of Prion Protein 106-126 (human)


Prion Protein 106-126 (human) is a peptide fragment of prion, it can induct neuronal apoptosis, antiproteinase K digestion, fiber formation, and mediate the conversion of normal cellular prion protein (PrPc) into pathogenic isoform (PrPSc). Prion Protein 106-126 (human) is generally used as the model to investigate neural degeneration of prion disease[1][2].

 Names

Name PrP [106-126]
Synonym More Synonyms

 Prion Protein 106-126 (human) Biological Activity

Description Prion Protein 106-126 (human) is a peptide fragment of prion, it can induct neuronal apoptosis, antiproteinase K digestion, fiber formation, and mediate the conversion of normal cellular prion protein (PrPc) into pathogenic isoform (PrPSc). Prion Protein 106-126 (human) is generally used as the model to investigate neural degeneration of prion disease[1][2].
Related Catalog
References

[1]. Forloni G, et, al. Neurotoxicity of a prion protein fragment. Nature. 1993 Apr 8; 362(6420): 543-6.

[2]. Hong JM, et, al. Human prion protein-mediated calcineurin activation induces neuron cell death via AMPK and autophagy pathway. Int J Biochem Cell Biol. 2020 Feb; 119: 105680.

 Chemical & Physical Properties

Molecular Formula C80H138N26O24S2
Molecular Weight 1912.24000
Exact Mass 1910.98000
PSA 839.96000
LogP 0.33420

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases S22-S24/25
RIDADR NONH for all modes of transport

 Synonyms

Prion Protein Fragment 106-126 Human
N-MPPP Hydrochloride