148869-05-0

148869-05-0 structure

Name: YM 511
Chemical Name: 4-[(4-bromophenyl)methyl-(1,2,4-triazol-4-yl)amino]benzonitrile
CAS Number: 148869-05-0
Molecular Formula: C₁₆H₁₂BrN₅
Molecular Weight: 354.20400
Create Date: 2016-07-13 16:37:32
Modify Date: 2024-01-06 17:35:08
YM511 is a highly specific non-steroidal aromatase inhibitor. YM511 inhibits aromatase activities in microsomes from rat ovary and human placenta competitively (IC50s of 0.4 and 0.12 nM, respectively). YM511 slightly inhibits production of other steroid hormones. YM511 has the potential for suppressing estrogen-dependent action research without affecting serum levels of other steroid hormones[1].

Name	4-[(4-bromophenyl)methyl-(1,2,4-triazol-4-yl)amino]benzonitrile
Synonyms	ym-511

Description	YM511 is a highly specific non-steroidal aromatase inhibitor. YM511 inhibits aromatase activities in microsomes from rat ovary and human placenta competitively (IC50s of 0.4 and 0.12 nM, respectively). YM511 slightly inhibits production of other steroid hormones. YM511 has the potential for suppressing estrogen-dependent action research without affecting serum levels of other steroid hormones[1].
Related Catalog	Research Areas >> Endocrinology Signaling Pathways >> Others >> Aromatase
References	[1]. M Kudoh, et al. The potent and selective inhibition of estrogen production by non-steroidal aromatase inhibitor, YM511. J Steroid Biochem Mol Biol. 1995 Sep;54(5-6):265-71.