1670-87-7
1670-87-7 structure
- Name: SD-169
- Chemical Name: 1H-Indole-5-carboxamide
- CAS Number: 1670-87-7
- Molecular Formula: C9H8N2O
- Molecular Weight: 160.173
- Catalog: Signaling Pathways MAPK/ERK Pathway p38 MAPK
- Create Date: 2018-02-10 08:00:00
- Modify Date: 2025-08-25 17:34:22
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SD-169 is an orally active ATP-competitive inhibitor of p38α MAPK, with an IC50 of 3.2 nM. SD-169 also weakly inhibits p38β MAPK with an IC50 of 122 nM. SD-169 prevents the development and progression of diabetes by inhibiting T cell infiltration and activation[1].
| Name | 1H-Indole-5-carboxamide |
|---|---|
| Synonyms |
1H-Indole-5-carboxamide
indole-5-carboxamide |
| Description | SD-169 is an orally active ATP-competitive inhibitor of p38α MAPK, with an IC50 of 3.2 nM. SD-169 also weakly inhibits p38β MAPK with an IC50 of 122 nM. SD-169 prevents the development and progression of diabetes by inhibiting T cell infiltration and activation[1]. |
|---|---|
| Related Catalog | |
| Target |
p38α MAPK:3.2 nM (IC50) p38β MAPK:122 nM (IC50) |
| In Vitro | SD-169 significantly reduces p38 and HSP60 expression in T cells of the pancreatic beta islets[1]. SD-169 demonstrates 38-fold potency against p38α MAP kinase (IC50=3.2 nM) than p38β MAP kinase (IC50=122 nM)[1]. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 457.6±18.0 °C at 760 mmHg |
| Melting Point | 159-163ºC |
| Molecular Formula | C9H8N2O |
| Molecular Weight | 160.173 |
| Flash Point | 230.6±21.2 °C |
| Exact Mass | 160.063660 |
| PSA | 58.88000 |
| LogP | 0.88 |
| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
| Index of Refraction | 1.717 |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xn: Harmful; |
| Risk Phrases | R22;R36/37/38 |
| Safety Phrases | S26 |
| RIDADR | NONH for all modes of transport |
| HS Code | 2933990090 |
|
~72%
1670-87-7 |
| Literature: LG LIFE SCIENCES LTD.; CHOI, Sung Pil; KIM, Geun Tae; SONG, Jeong Uk; KIM, Tae Hun; LIM, Dong Chul; KANG, Seung Wan; KIM, Hyung Jin Patent: WO2010/93191 A2, 2010 ; Location in patent: Paragraph 376-380 ; WO 2010/093191 A2 |
|
~%
1670-87-7 |
| Literature: Heterocycles, , vol. 34, # 6 p. 1169 - 1175 |
| Precursor 3 | |
|---|---|
| DownStream 1 | |
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |