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202466-68-0

202466-68-0 structure
202466-68-0 structure
  • Name: Ro 04-6790
  • Chemical Name: Ro 04-6790 dihydrochloride
  • CAS Number: 202466-68-0
  • Molecular Formula: C12H16N6O2S
  • Molecular Weight: 308.359
  • Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
  • Create Date: 2018-12-18 10:57:58
  • Modify Date: 2024-01-08 13:07:16
  • Ro 04-6790 is a potent, competitive and selective 5-HT6 receptor antagonist with pKi values of 7.26, 7.35 for rat and human 5-HT6 receptors, respectively. Ro 04-6790 has no affinity at other receptors[1].

Name Ro 04-6790 dihydrochloride
Synonyms 4-Amino-N-[2,6-bis(methylamino)-4-pyrimidinyl]benzenesulfonamide
4-Amino-N-[2,6-bis(methylamino)-4-pyrimidinyl]benzenesulfonamide dihydrobromide
Benzenesulfonamide, 4-amino-N-[2,6-bis(methylamino)-4-pyrimidinyl]-
4-Amino-N-[2,6-bis(methylamino)pyrimidin-4-yl]benzenesulfonamide
Ro 04-6790
4-amino-N-(2,6-bis-methylaminopyrimidin-4-yl)benzenesulfonamide
Description Ro 04-6790 is a potent, competitive and selective 5-HT6 receptor antagonist with pKi values of 7.26, 7.35 for rat and human 5-HT6 receptors, respectively. Ro 04-6790 has no affinity at other receptors[1].
Related Catalog
Target

Rat 5-HT6 Receptor:7.26 (pKi)

Human 5-HT6 Receptor:7.35 (pKi)

In Vitro Ro 04-6790 has over 100 fold selective for the 5-HT6 receptor compared to other receptor binding sites (IC50>10 μM)[1].
In Vivo Ro 04-6790 (10 mg/kg, SC) produces a modest (50%) increase in ACh outflow in adult male Wistar rats of 250-300 g (this effect is not statistically different from the action of vehicle)[2].
References

[1]. A J Sleight, et al. Characterization of Ro 04-6790 and Ro 63-0563: potent and selective antagonists at human and rat 5-HT6 receptors. Br J Pharmacol. 1998 Jun;124(3):556-62.

[2]. Sudabeh Shirazi-Southall, et al. Effects of typical and atypical antipsychotics and receptor selective compounds on acetylcholine efflux in the hippocampus of the rat. Neuropsychopharmacology. 2002 May;26(5):583-94.

Density 1.5±0.1 g/cm3
Boiling Point 595.8±60.0 °C at 760 mmHg
Molecular Formula C12H16N6O2S
Molecular Weight 308.359
Flash Point 314.1±32.9 °C
Exact Mass 308.105530
PSA 130.41000
LogP -0.52
Vapour Pressure 0.0±1.7 mmHg at 25°C
Index of Refraction 1.700
Hazard Codes Xi
RIDADR NONH for all modes of transport
RTECS DA9462500
HS Code 2935009090
HS Code 2935009090
Summary 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%