Ro 04-6790

Modify Date: 2024-01-08 13:07:16

Ro 04-6790 structure	Common Name	Ro 04-6790
	CAS Number	202466-68-0	Molecular Weight	308.359
	Density	1.5±0.1 g/cm3	Boiling Point	595.8±60.0 °C at 760 mmHg
	Molecular Formula	C₁₂H₁₆N₆O₂S	Melting Point	N/A
	MSDS	USA	Flash Point	314.1±32.9 °C

Use of Ro 04-6790

Ro 04-6790 is a potent, competitive and selective 5-HT6 receptor antagonist with pKi values of 7.26, 7.35 for rat and human 5-HT6 receptors, respectively. Ro 04-6790 has no affinity at other receptors[1].

Name	Ro 04-6790 dihydrochloride
Synonym	More Synonyms

Description	Ro 04-6790 is a potent, competitive and selective 5-HT6 receptor antagonist with pKi values of 7.26, 7.35 for rat and human 5-HT6 receptors, respectively. Ro 04-6790 has no affinity at other receptors[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
Target	Rat 5-HT6 Receptor:7.26 (pKi) Human 5-HT6 Receptor:7.35 (pKi)
In Vitro	Ro 04-6790 has over 100 fold selective for the 5-HT6 receptor compared to other receptor binding sites (IC50>10 μM)[1].
In Vivo	Ro 04-6790 (10 mg/kg, SC) produces a modest (50%) increase in ACh outflow in adult male Wistar rats of 250-300 g (this effect is not statistically different from the action of vehicle)[2].
References	[1]. A J Sleight, et al. Characterization of Ro 04-6790 and Ro 63-0563: potent and selective antagonists at human and rat 5-HT6 receptors. Br J Pharmacol. 1998 Jun;124(3):556-62. [2]. Sudabeh Shirazi-Southall, et al. Effects of typical and atypical antipsychotics and receptor selective compounds on acetylcholine efflux in the hippocampus of the rat. Neuropsychopharmacology. 2002 May;26(5):583-94.

Density	1.5±0.1 g/cm3
Boiling Point	595.8±60.0 °C at 760 mmHg
Molecular Formula	C₁₂H₁₆N₆O₂S
Molecular Weight	308.359
Flash Point	314.1±32.9 °C
Exact Mass	308.105530
PSA	130.41000
LogP	-0.52
Vapour Pressure	0.0±1.7 mmHg at 25°C
Index of Refraction	1.700

Hazard Codes	Xi
RIDADR	NONH for all modes of transport
RTECS	DA9462500
HS Code	2935009090

HS Code	2935009090
Summary	2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

Characterization of Ro 04-6790 and Ro 63-0563: potent and selective antagonists at human and rat 5-HT6 receptors.

Br. J. Pharmacol. 124 , 556-562, (1998)

1. This study describes the in vitro characterization of two potent and selective 5-HT6 receptor antagonists at the rat and human recombinant 5-HT6 receptor. 2. In binding assays with [3H]-LSD, 4-amin...

Investigation of stretching behaviour induced by the selective 5-HT6 receptor antagonist, Ro 04-6790, in rats.

Br. J. Pharmacol. 126 , 1537-1542, (1999)

1. The present study examined the effects of the selective 5-HT6 receptor antagonist 4-amino-N-(2, 6 bis-methylamino-pyrimidin-4-yl)-benzene sulphonamide (Ro 04-6790) on locomotor activity and uncondi...

4-Amino-N-[2,6-bis(methylamino)-4-pyrimidinyl]benzenesulfonamide

4-Amino-N-[2,6-bis(methylamino)-4-pyrimidinyl]benzenesulfonamide dihydrobromide

Benzenesulfonamide, 4-amino-N-[2,6-bis(methylamino)-4-pyrimidinyl]-

4-Amino-N-[2,6-bis(methylamino)pyrimidin-4-yl]benzenesulfonamide

Ro 04-6790

4-amino-N-(2,6-bis-methylaminopyrimidin-4-yl)benzenesulfonamide