- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: AC-93253 iodide
- Price: Check
- Purity: 98.0%
- Stocking Period: 10 Day
- Contact: Yang
- Email: sales@echemcloud.com
- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: AC-93253 iodide
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Stocking Period: 1 Day
- Contact: Tony Lai
- Email: order@dcchemicals.com
- DC Chemicals Limited
- China
- Product Name: AC-93253 iodide
- Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
- Nanjing Peptide Biotech Ltd
- China
- Product Name: ac-93253 iodide
- Price: ￥Inquiry/10g ￥Inquiry/100g ￥Inquiry/1kg ￥Inquiry/10kg
- Purity: 98.0%
- Stocking Period: 7 Day
- Contact: jom
- Email: chenglong.fan@njpeptide.com
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: AC-93253 IODIDE
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Ms Wang
- Email: enquiry@dycnchem.com
108527-83-9
108527-83-9 structure
- Name: ac-93253 iodide
- Chemical Name: ac-93253 iodide
- CAS Number: 108527-83-9
- Molecular Formula: C23H25IN2S
- Molecular Weight: 488.42700
- Catalog: Signaling Pathways Cell Cycle/DNA Damage Sirtuin
- Create Date: 2017-08-25 03:13:54
- Modify Date: 2025-08-29 10:31:22
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AC-93253 is a selective, potent SIRT2 inhibitor. AC93253 can inhibit SIRT2 with an IC50 value of 6 μM. AC93253 can be used for the research of tumors[1].
| Name | ac-93253 iodide |
|---|
| Description | AC-93253 is a selective, potent SIRT2 inhibitor. AC93253 can inhibit SIRT2 with an IC50 value of 6 μM. AC93253 can be used for the research of tumors[1]. |
|---|---|
| Related Catalog | |
| Target |
SIRT1:45.3 μM (IC50) SIRT2:6 μM (IC50) SIRT3:24.6 μM (IC50) |
| In Vitro | AC93253 可抑制 SIRT1、SIRT2 和 SIRT3，IC50 值分别为 45.3 μM、6 μM 和 24.6 μM[1]。 AC-93253（0、2、5、10 μM；16 h）显著增强微管蛋白、p53 和组蛋白 H4 的乙酰化[1]。 AC-93253 对四种肿瘤细胞系表现出选择性细胞毒性，IC50 值范围为 10 - 100 nM[1]。 AC-93253 显著触发细胞凋亡[1]。 Western Blot Analysis[1] Cell Line: NCI-H460 cells, HeLa cells Concentration: 0, 2, 5, 10 μM Incubation Time: 16 h Result: Increased the acetylation levels of a-tubulin in a dose-dependent manner. Increased the level of histone protein and p53. |
| References |
| Molecular Formula | C23H25IN2S |
|---|---|
| Molecular Weight | 488.42700 |
| Exact Mass | 488.07800 |
| PSA | 35.36000 |
| LogP | 2.60240 |
| RIDADR | NONH for all modes of transport |
|---|
|
~%
108527-83-9 |
| Literature: Hamer et al. Journal of the Chemical Society, 1948 , p. 1872,887 |
| Precursor 2 | |
|---|---|
| DownStream 0 | |