ac-93253 iodide
Modify Date: 2025-08-29 10:31:22
ac-93253 iodide structure
|
Common Name | ac-93253 iodide | ||
|---|---|---|---|---|
| CAS Number | 108527-83-9 | Molecular Weight | 488.42700 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C23H25IN2S | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
Use of ac-93253 iodideAC-93253 is a selective, potent SIRT2 inhibitor. AC93253 can inhibit SIRT2 with an IC50 value of 6 μM. AC93253 can be used for the research of tumors[1]. |
| Name | ac-93253 iodide |
|---|
| Description | AC-93253 is a selective, potent SIRT2 inhibitor. AC93253 can inhibit SIRT2 with an IC50 value of 6 μM. AC93253 can be used for the research of tumors[1]. |
|---|---|
| Related Catalog | |
| Target |
SIRT1:45.3 μM (IC50) SIRT2:6 μM (IC50) SIRT3:24.6 μM (IC50) |
| In Vitro | AC93253 可抑制 SIRT1、SIRT2 和 SIRT3，IC50 值分别为 45.3 μM、6 μM 和 24.6 μM[1]。 AC-93253（0、2、5、10 μM；16 h）显著增强微管蛋白、p53 和组蛋白 H4 的乙酰化[1]。 AC-93253 对四种肿瘤细胞系表现出选择性细胞毒性，IC50 值范围为 10 - 100 nM[1]。 AC-93253 显著触发细胞凋亡[1]。 Western Blot Analysis[1] Cell Line: NCI-H460 cells, HeLa cells Concentration: 0, 2, 5, 10 μM Incubation Time: 16 h Result: Increased the acetylation levels of a-tubulin in a dose-dependent manner. Increased the level of histone protein and p53. |
| References |
| Molecular Formula | C23H25IN2S |
|---|---|
| Molecular Weight | 488.42700 |
| Exact Mass | 488.07800 |
| PSA | 35.36000 |
| LogP | 2.60240 |
| RIDADR | NONH for all modes of transport |
|---|
|
~%
ac-93253 iodide CAS#:108527-83-9 |
| Literature: Hamer et al. Journal of the Chemical Society, 1948 , p. 1872,887 |
| Precursor 2 | |
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| DownStream 0 | |
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