Shanghai Nianxing Industrial Co., Ltd
China
Product Name: CNQX
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Purity: 98.0%
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DC Chemicals Limited
China
Product Name: CNQX
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ShangHai DC Chemicals Co.,Ltd
China
Product Name: CNQX
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Purity: 98.9%
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 6-cyano-7-nitroquinoxaline-2,3-dione
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Purity: 98.0%
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115066-14-3

115066-14-3 structure

115066-14-3 structure

Name: CNQX
Chemical Name: 6-cyano-7-nitroquinoxaline-2,3-dione
CAS Number: 115066-14-3
Molecular Formula: C₉H₄N₄O₄
Molecular Weight: 232.152
Catalog: Signaling Pathways Membrane Transporter/Ion Channel iGluR
Create Date: 2018-12-19 22:31:16
Modify Date: 2024-01-02 10:20:39
CNQX (FG9065) is a potent AMPA/kainate receptor antagonist.

Name	6-cyano-7-nitroquinoxaline-2,3-dione
Synonyms	CNQX disodium salt hydrate CNQX 2NA 6-Nitro-7-cyanoquinoxaline-2,3-dione MFCD00069232 6-Cyano-7-nitroquinoxaline-2,3-dione FG-9065 7-Nitro-2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-carbonitrile 2,3-Dihydroxy-7-nitroquinoxaline-6-carbonitrile 7-Nitro-2,3-dioxo-1,2,3,4-tetrahydro-6-quinoxalinecarbonitrile CNQX DISODIUM CNOX CNQX DISODIUM SALT CNQX 6-Quinoxalinecarbonitrile, 1,2,3,4-tetrahydro-7-nitro-2,3-dioxo- 6-Cyano-7-nitroquinoxaline-2,3-dione disodium salt hydrate FG-9065 CNQX DISODIUM KAINATE/AMPA RECEPTOR

Description	CNQX (FG9065) is a potent AMPA/kainate receptor antagonist.
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Neurological Disease
In Vitro	In rat hippocampal slices bathed in Mg2+-free medium, 10 μM CNQX reversibly blocks responses to a-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA), quisqualate and kainate but not NMDA[1]. Superfusion of hippocampal slices with 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX, 2-5 μM) reversibly blocks the Schaffer collateral and mossy fibre excitatory postsynaptic potential (EPSP), while sparing the fast and slow GABA-mediated inhibition[2]. CNQX (1-5 μM) produces a selective and dose-dependent reduction in the amplitude of the monosynaptic component of the DR-VRR recorded from lumbar spinal segments[3]. CNQX-mediated depolarizations are mediated by AMPAR but not kainate receptors in TRN neurons[4].
In Vivo	The bilateral infusion of CNQX (0.5 or 1.25 μg) into the amygdala or dorsal hippocampus 10 min prior to a retention test partially blocks the expression of stepdown inhibitory avoidance in rats 24 h after training. CNQX causes a complete blockade at a dose of 0.5 μg[5].
Cell Assay	CNQX is applied by injecting a bolus into the input line of the chamber over 60 s using a motorized syringe pump. In a subpopulation of neurons, CNQX is bath applied for 5 min. Control injections of physiological saline or vehicle (DMSO) does not alter membrane potential/input resistance during voltage recordings[4].
References	[1]. Blake JF, et al. CNQX blocks acidic amino acid induced depolarizations and synaptic components mediated by non-NMDA receptors in rathippocampal slices. Neurosci Lett. 1988 Jun 29;89(2):182-6. [2]. Neuman RS, et al. Blockade of excitatory synaptic transmission by 6-cyano-7-nitroquinoxaline-2,3-dione(CNQX) in the hippocampus in vitro. Neurosci Lett. 1988 Sep 23;92(1):64-8. [3]. Alford S, et al. CNQX and DNQX block non-NMDA synaptic transmission but not NMDA-evoked locomotion in lamprey spinal cord. Brain Res. 1990 Jan 8;506(2):297-302. [4]. Lee SH, et al. Selective excitatory actions of DNQX and CNQX in rat thalamic neurons. J Neurophysiol. 2010 Apr;103(4):1728-34. [5]. Kim M, et al. Infusion of the non-NMDA receptor antagonist CNQX into the amygdala blocks the expression of fear-potentiated startle. Behav Neural Biol. 1993 Jan;59(1):5-8.

Density	1.7±0.1 g/cm3
Boiling Point	659.3ºC at 760 mmHg
Melting Point	300 °C
Molecular Formula	C₉H₄N₄O₄
Molecular Weight	232.152
Flash Point	352.6ºC
Exact Mass	232.023254
PSA	135.33000
LogP	0.64
Vapour Pressure	0.001mmHg at 25°C
Index of Refraction	1.699
Storage condition	Desiccate at RT
Stability	Store Tightly Sealed at RT
Water Solubility	H2O: 10 mg/mL

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi: Irritant;
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3