Shanghai Nianxing Industrial Co., Ltd
China
Product Name: BRD 9757
Price: Check
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang
Email: sales@echemcloud.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: BRD9757
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

DC Chemicals Limited
China
Product Name: BRD9757
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

1423058-85-8

1423058-85-8 structure

1423058-85-8 structure

Name: BRD 9757
Chemical Name: brd9757
CAS Number: 1423058-85-8
Molecular Formula: C₆H₉NO₂
Molecular Weight: 127.14100
Catalog: Signaling Pathways Cell Cycle/DNA Damage HDAC
Create Date: 2018-02-03 08:38:37
Modify Date: 2024-01-09 14:06:15
BRD9757 is a potent, capless and selective HDAC6 inhibitor with an IC50 of 30 nM. BRD9757 shows excellent selectivity toward HDAC6 versus the class I (>20-fold) and class II (>400-fold) HDACs[1].

Name	brd9757

Description	BRD9757 is a potent, capless and selective HDAC6 inhibitor with an IC50 of 30 nM. BRD9757 shows excellent selectivity toward HDAC6 versus the class I (>20-fold) and class II (>400-fold) HDACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC Signaling Pathways >> Epigenetics >> HDAC
Target	HDAC6:0.03 μM (IC50) HDAC1:0.638 μM (IC50) HDAC2:1.79 μM (IC50) HDAC3:0.694 μM (IC50) HDAC4:21.80 μM (IC50) HDAC5:18.32 μM (IC50) HDAC7:12.61 μM (IC50) HDAC8:1.09 μM (IC50) HDAC9:>33.33 μM (IC50)
In Vitro	BRD9757（化合物 14）对抗 HDAC1、HDAC2、HDAC3、HDAC4、HDAC5、HDAC7、HDAC8 和 HDAC9，IC50 值分别为 0.638 μM、1.79 μM、0.694 μM、21.80 μM、18.32 μM、12.61 μM、1.09 μM 和 >33.33 μM[1]。 BRD9757（化合物 14；10-30 μM；24 小时）选择性地增加 Ac-tubulin 的水平，而不增加组蛋白乙酰化[1]。 Western Blot Analysis[1] Cell Line: HeLa cells Concentration: 10 μM and 30 μM Incubation Time: for 24 h Result: Increased the level of Ac-tubulin.
References	[1]. Florence F Wagner, et al. Potent and selective inhibition of histone deacetylase 6 (HDAC6) does not require a surface-binding motif. J Med Chem. 2013 Feb 28;56(4):1772-6.

Molecular Formula	C₆H₉NO₂
Molecular Weight	127.14100
Exact Mass	127.06300
PSA	49.33000
LogP	0.99300

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H319-H412
Precautionary Statements	P273-P305 + P351 + P338
RIDADR	NONH for all modes of transport

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