7724-76-7

7724-76-7 structure

Name: N6-Isopentenyladenosine
Chemical Name: N6-(Δ2-isopentenyl)adenosine
CAS Number: 7724-76-7
Molecular Formula: C₁₅H₂₁N₅O₄
Molecular Weight: 335.358
Catalog: Biochemical Nucleoside drugs Nucleoside intermediate
Create Date: 2018-08-07 18:21:07
Modify Date: 2024-01-02 11:39:46
N6-Isopentenyladenosine (Riboprine), an RNA modification found in cytokinins, which regulate plant growth/differentiation, and a subset of tRNAs, where it improves the efficiency and accuracy of translation. N6-Isopentenyladenosine, an end product of the mevalonate pathway, is an autophagy inhibitor with an interesting anti-melanoma activity[1][2][3].

Name	N6-(Δ2-isopentenyl)adenosine
Synonyms	N-(3-Methyl-2-buten-1-yl)adenosine N-(3-Methylbut-2-en-1-yl)adenosine N6-(δ2-Isopentenyl)adenosine 6-(g,g-Dimethylallylamino)purine Riboside N-6-(δ-2-Isopentenyl)adenosine isopentenyl-Adenosine-[d6] Adenosine, N-(3-methyl-2-butenyl)- riboprina 6-N-((3-Methyl-2-butenyl)amino)-9-b-D-ribofuranosyl-9H-purine N6-isopentenyladenosine 6-(γ,γ-Dimethylallylamino)purine riboside riboprine N6-ISOPENTENYLADENOSINE-D6 isopentenyladenosine riboprinum Isopentenyl-Adenosine N(6)-(δ(2)-isopentenyl)adenosine 2-IP RIBOSIDE EINECS 231-771-3 N6-(D2-Isopentenyl)adenosine Adenosine, N-(3-methyl-2-buten-1-yl)- N-6-(δ-2-Isopentenyl)adenosinehemihydrate 2ipa N(6)-(Delta(2)-isopentenyl)adenosine n-isopentenyladenosine MFCD00005741

Description	N6-Isopentenyladenosine (Riboprine), an RNA modification found in cytokinins, which regulate plant growth/differentiation, and a subset of tRNAs, where it improves the efficiency and accuracy of translation. N6-Isopentenyladenosine, an end product of the mevalonate pathway, is an autophagy inhibitor with an interesting anti-melanoma activity[1][2][3].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Autophagy >> Autophagy
In Vitro	N6-isopentenyladenosine dual targeting of AMPK and Rab7 prenylation inhibits melanoma growth through the impairment of autophagic flux[2].
References	[1]. Colombo F, et al. Pharmacogenomics and analogues of the antitumour agent N6-isopentenyladenosine. Int J Cancer. 2009;124(9):2179-2185. [2]. Ranieri R, et al. N6-isopentenyladenosine dual targeting of AMPK and Rab7 prenylation inhibits melanoma growth through the impairment of autophagic flux. Cell Death Differ. 2018;25(2):353-367. [3]. Cheng HP, et al. Chemical Deprenylation of N6 -Isopentenyladenosine (i6 A) RNA. Angew Chem Int Ed Engl. 2020;59(26):10645-10650.

REFERENCE :: BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 18,847,1969