N6-Isopentenyladenosine

Modify Date: 2024-01-02 11:39:46

N6-Isopentenyladenosine structure	Common Name	N6-Isopentenyladenosine
	CAS Number	7724-76-7	Molecular Weight	335.358
	Density	1.6±0.1 g/cm3	Boiling Point	647.2±65.0 °C at 760 mmHg
	Molecular Formula	C₁₅H₂₁N₅O₄	Melting Point	143-146°C
	MSDS	N/A	Flash Point	345.2±34.3 °C

Use of N6-Isopentenyladenosine

N6-Isopentenyladenosine (Riboprine), an RNA modification found in cytokinins, which regulate plant growth/differentiation, and a subset of tRNAs, where it improves the efficiency and accuracy of translation. N6-Isopentenyladenosine, an end product of the mevalonate pathway, is an autophagy inhibitor with an interesting anti-melanoma activity[1][2][3].

Name	N6-(Δ2-isopentenyl)adenosine
Synonym	More Synonyms

Description	N6-Isopentenyladenosine (Riboprine), an RNA modification found in cytokinins, which regulate plant growth/differentiation, and a subset of tRNAs, where it improves the efficiency and accuracy of translation. N6-Isopentenyladenosine, an end product of the mevalonate pathway, is an autophagy inhibitor with an interesting anti-melanoma activity[1][2][3].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Autophagy >> Autophagy
In Vitro	N6-isopentenyladenosine dual targeting of AMPK and Rab7 prenylation inhibits melanoma growth through the impairment of autophagic flux[2].
References	[1]. Colombo F, et al. Pharmacogenomics and analogues of the antitumour agent N6-isopentenyladenosine. Int J Cancer. 2009;124(9):2179-2185. [2]. Ranieri R, et al. N6-isopentenyladenosine dual targeting of AMPK and Rab7 prenylation inhibits melanoma growth through the impairment of autophagic flux. Cell Death Differ. 2018;25(2):353-367. [3]. Cheng HP, et al. Chemical Deprenylation of N6 -Isopentenyladenosine (i6 A) RNA. Angew Chem Int Ed Engl. 2020;59(26):10645-10650.

Density	1.6±0.1 g/cm3
Boiling Point	647.2±65.0 °C at 760 mmHg
Melting Point	143-146°C
Molecular Formula	C₁₅H₂₁N₅O₄
Molecular Weight	335.358
Flash Point	345.2±34.3 °C
Exact Mass	335.159363
PSA	125.55000
LogP	1.31
Vapour Pressure	0.0±2.0 mmHg at 25°C
Index of Refraction	1.708
Storage condition	−20°C

N6-Isopentenyladenosine MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AU7404910

CHEMICAL NAME :: Adenosine, N-(3-methyl-2-butenyl)-

CAS REGISTRY NUMBER :: 7724-76-7

LAST UPDATED :: 198602

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C15-H21-N5-O4

MOLECULAR WEIGHT :: 335.41

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Rodent - rat Cells - not otherwise specified

DOSE/DURATION :: 3300 ug/L

REFERENCE :: BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 18,847,1969

Hazard Codes	Xi
Safety Phrases	24/25
WGK Germany	3
RTECS	AU7404910

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